Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001

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Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001. / Devi, Sagarika; Kiesewalter, Heiko T.; Kovács, Renátó; Frisvad, Jens Christian; Weber, Tilmann; Larsen, Thomas Ostenfeld; Kovács, Ákos T.; Ding, Ling.

In: Synthetic and Systems Biotechnology, Vol. 4, No. 3, 2019, p. 142-149.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Devi, S, Kiesewalter, HT, Kovács, R, Frisvad, JC, Weber, T, Larsen, TO, Kovács, ÁT & Ding, L 2019, 'Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001', Synthetic and Systems Biotechnology, vol. 4, no. 3, pp. 142-149. https://doi.org/10.1016/j.synbio.2019.08.002

APA

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T., & Ding, L. (2019). Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001. Synthetic and Systems Biotechnology, 4(3), 142-149. https://doi.org/10.1016/j.synbio.2019.08.002

Vancouver

Devi S, Kiesewalter HT, Kovács R, Frisvad JC, Weber T, Larsen TO et al. Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001. Synthetic and Systems Biotechnology. 2019;4(3):142-149. https://doi.org/10.1016/j.synbio.2019.08.002

Author

Devi, Sagarika ; Kiesewalter, Heiko T. ; Kovács, Renátó ; Frisvad, Jens Christian ; Weber, Tilmann ; Larsen, Thomas Ostenfeld ; Kovács, Ákos T. ; Ding, Ling. / Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001. In: Synthetic and Systems Biotechnology. 2019 ; Vol. 4, No. 3. pp. 142-149.

Bibtex

@article{54d84ddca2d94d00b5964523c11e4158,
title = "Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001",
abstract = "For a safe and sustainable environment, effective microbes as biocontrol agents are in high demand. We have isolated a new Bacillus velezensis strain DTU001, investigated its antifungal spectrum, sequenced its genome, and uncovered the production of lipopeptides in HPLC-HRMS analysis. To test the antifungal efficacy, extracts of B. velezensis DTU001 was tested against a range of twenty human or plant pathogenic fungi. We demonstrate that inhibitory potential of B. velezensis DTU001 against selected fungi is superior in comparison to single lipopeptide, either iturin or fengycin. The isolate showed analogous biofilm formation to other closely related Bacilli. To further support the biocontrol properties of the isolate, coculture with Candida albicans demonstrated that B. velezensis DTU001 exhibited excellent antiproliferation effect against C. albicans. In summary, the described isolate is a potential antifungal agent with a broad antifungal spectrum that might assist our aims to avoid hazardous pathogenic fungi and provide alternative to toxicity caused by chemicals.",
keywords = "Bacillus velezensis, Biocontrol, Biofilm, Candida albicans, Secondary metabolites",
author = "Sagarika Devi and Kiesewalter, {Heiko T.} and Ren{\'a}t{\'o} Kov{\'a}cs and Frisvad, {Jens Christian} and Tilmann Weber and Larsen, {Thomas Ostenfeld} and Kov{\'a}cs, {{\'A}kos T.} and Ling Ding",
note = "Publisher Copyright: {\textcopyright} 2019",
year = "2019",
doi = "10.1016/j.synbio.2019.08.002",
language = "English",
volume = "4",
pages = "142--149",
journal = "Synthetic and Systems Biotechnology",
issn = "2405-805X",
publisher = "KeAi Communications Co",
number = "3",

}

RIS

TY - JOUR

T1 - Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001

AU - Devi, Sagarika

AU - Kiesewalter, Heiko T.

AU - Kovács, Renátó

AU - Frisvad, Jens Christian

AU - Weber, Tilmann

AU - Larsen, Thomas Ostenfeld

AU - Kovács, Ákos T.

AU - Ding, Ling

N1 - Publisher Copyright: © 2019

PY - 2019

Y1 - 2019

N2 - For a safe and sustainable environment, effective microbes as biocontrol agents are in high demand. We have isolated a new Bacillus velezensis strain DTU001, investigated its antifungal spectrum, sequenced its genome, and uncovered the production of lipopeptides in HPLC-HRMS analysis. To test the antifungal efficacy, extracts of B. velezensis DTU001 was tested against a range of twenty human or plant pathogenic fungi. We demonstrate that inhibitory potential of B. velezensis DTU001 against selected fungi is superior in comparison to single lipopeptide, either iturin or fengycin. The isolate showed analogous biofilm formation to other closely related Bacilli. To further support the biocontrol properties of the isolate, coculture with Candida albicans demonstrated that B. velezensis DTU001 exhibited excellent antiproliferation effect against C. albicans. In summary, the described isolate is a potential antifungal agent with a broad antifungal spectrum that might assist our aims to avoid hazardous pathogenic fungi and provide alternative to toxicity caused by chemicals.

AB - For a safe and sustainable environment, effective microbes as biocontrol agents are in high demand. We have isolated a new Bacillus velezensis strain DTU001, investigated its antifungal spectrum, sequenced its genome, and uncovered the production of lipopeptides in HPLC-HRMS analysis. To test the antifungal efficacy, extracts of B. velezensis DTU001 was tested against a range of twenty human or plant pathogenic fungi. We demonstrate that inhibitory potential of B. velezensis DTU001 against selected fungi is superior in comparison to single lipopeptide, either iturin or fengycin. The isolate showed analogous biofilm formation to other closely related Bacilli. To further support the biocontrol properties of the isolate, coculture with Candida albicans demonstrated that B. velezensis DTU001 exhibited excellent antiproliferation effect against C. albicans. In summary, the described isolate is a potential antifungal agent with a broad antifungal spectrum that might assist our aims to avoid hazardous pathogenic fungi and provide alternative to toxicity caused by chemicals.

KW - Bacillus velezensis

KW - Biocontrol

KW - Biofilm

KW - Candida albicans

KW - Secondary metabolites

U2 - 10.1016/j.synbio.2019.08.002

DO - 10.1016/j.synbio.2019.08.002

M3 - Journal article

AN - SCOPUS:85071250469

VL - 4

SP - 142

EP - 149

JO - Synthetic and Systems Biotechnology

JF - Synthetic and Systems Biotechnology

SN - 2405-805X

IS - 3

ER -

ID: 290666513