Cimetidine treatment of protein-losing gastropathy (Ménétrier's disease). A clinical and pathophysiological study

Research output: Contribution to journal › Journal article › Research › peer-review

  • E Krag
  • H J Frederiksen
  • N Olsen
  • Jens Henrik Sahl Henriksen
In a 47-year-old male with Ménétrier's disease (protein-losing gastropathy) the histamine-H2-receptor antagonist Cimetidine stops the protein loss and improves the clinical condition. Gastric perfusion studies on net and bidirectional ionic fluxes, protein secretion rates, and permeability, with simultaneous recording of the transmural electrical potential difference indicate that Cimetidine decreases a paracellular protein secretion by 'tightening' the tight junctions of the gastric epithelium.
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume13
Issue number5
Pages (from-to)636-9
Number of pages3
ISSN0036-5521
Publication statusPublished - 1978

Bibliographical note

Keywords: Cimetidine; Guanidines; Humans; Intestinal Absorption; Male; Membrane Potentials; Middle Aged; Protein-Losing Enteropathies; Proteins; Water-Electrolyte Balance

ID: 19398750