C/EBPalpha: a tumour suppressor in multiple tissues?
Research output: Contribution to journal › Journal article › Research › peer-review
The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.
Original language | English |
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Journal | BBA General Subjects |
Volume | 1766 |
Issue number | 1 |
Pages (from-to) | 88-103 |
Number of pages | 15 |
ISSN | 0304-4165 |
DOIs | |
Publication status | Published - 2006 |
Bibliographical note
Keywords: Animals; CCAAT-Enhancer-Binding Protein-alpha; Genes, Tumor Suppressor; Humans; Neoplasms; Tissue Distribution
ID: 5140564