C/EBPalpha: a tumour suppressor in multiple tissues?

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Standard

C/EBPalpha: a tumour suppressor in multiple tissues? / Schuster, Mikkel Bruhn; Porse, Bo Torben.

In: BBA General Subjects, Vol. 1766, No. 1, 2006, p. 88-103.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schuster, MB & Porse, BT 2006, 'C/EBPalpha: a tumour suppressor in multiple tissues?', BBA General Subjects, vol. 1766, no. 1, pp. 88-103. https://doi.org/10.1016/j.bbcan.2006.02.003

APA

Schuster, M. B., & Porse, B. T. (2006). C/EBPalpha: a tumour suppressor in multiple tissues? BBA General Subjects, 1766(1), 88-103. https://doi.org/10.1016/j.bbcan.2006.02.003

Vancouver

Schuster MB, Porse BT. C/EBPalpha: a tumour suppressor in multiple tissues? BBA General Subjects. 2006;1766(1):88-103. https://doi.org/10.1016/j.bbcan.2006.02.003

Author

Schuster, Mikkel Bruhn ; Porse, Bo Torben. / C/EBPalpha: a tumour suppressor in multiple tissues?. In: BBA General Subjects. 2006 ; Vol. 1766, No. 1. pp. 88-103.

Bibtex

@article{86681750588b11dd8d9f000ea68e967b,
title = "C/EBPalpha: a tumour suppressor in multiple tissues?",
abstract = "The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.",
author = "Schuster, {Mikkel Bruhn} and Porse, {Bo Torben}",
note = "Keywords: Animals; CCAAT-Enhancer-Binding Protein-alpha; Genes, Tumor Suppressor; Humans; Neoplasms; Tissue Distribution",
year = "2006",
doi = "10.1016/j.bbcan.2006.02.003",
language = "English",
volume = "1766",
pages = "88--103",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - C/EBPalpha: a tumour suppressor in multiple tissues?

AU - Schuster, Mikkel Bruhn

AU - Porse, Bo Torben

N1 - Keywords: Animals; CCAAT-Enhancer-Binding Protein-alpha; Genes, Tumor Suppressor; Humans; Neoplasms; Tissue Distribution

PY - 2006

Y1 - 2006

N2 - The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.

AB - The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.

U2 - 10.1016/j.bbcan.2006.02.003

DO - 10.1016/j.bbcan.2006.02.003

M3 - Journal article

C2 - 16616425

VL - 1766

SP - 88

EP - 103

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 1

ER -

ID: 5140564