Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies. / Jensen, Trine Hammer; Nielsen, Line; Aasted, Bent; Pertoldi, Cino; Blixenkrone-Møller, Merete.

In: Vaccine, Vol. 33, No. 11, 2015, p. 1375-1381.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, TH, Nielsen, L, Aasted, B, Pertoldi, C & Blixenkrone-Møller, M 2015, 'Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies', Vaccine, vol. 33, no. 11, pp. 1375-1381. https://doi.org/10.1016/j.vaccine.2015.01.029

APA

Jensen, T. H., Nielsen, L., Aasted, B., Pertoldi, C., & Blixenkrone-Møller, M. (2015). Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies. Vaccine, 33(11), 1375-1381. https://doi.org/10.1016/j.vaccine.2015.01.029

Vancouver

Jensen TH, Nielsen L, Aasted B, Pertoldi C, Blixenkrone-Møller M. Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies. Vaccine. 2015;33(11):1375-1381. https://doi.org/10.1016/j.vaccine.2015.01.029

Author

Jensen, Trine Hammer ; Nielsen, Line ; Aasted, Bent ; Pertoldi, Cino ; Blixenkrone-Møller, Merete. / Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies. In: Vaccine. 2015 ; Vol. 33, No. 11. pp. 1375-1381.

Bibtex

@article{e85062d67e774ec5873991f086e2e675,
title = "Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies",
abstract = "Canine distemper virus (CDV) is highly contagious and can cause severe disease against which conventional live vaccines are ineffective in the presence of maternal antibodies. Vaccination in the presences of maternal antibodies was challenged by vaccination of 5 days old and 3 weeks old mink kits with CDV DNA vaccines. Virus neutralising (VN) antibody responses were induced in mink kits vaccinated with a plasmid encoding the haemaglutinin protein (H) of CDV (n=5, pCDV-H) or a combination of the H, fusion (F) and nucleoprotein (N) of CDV (n=5, pCDV-HFN). These DNA vaccinated kits were protected against virulent experimental infection with field strains of CDV. The pCDV-H was more efficient in inducing protective immunity in the presence of maternal antibodies compared to the pCDV-HFN. The results show that DNA vaccination with the pCDV-H or pCDV-HFN (n=4) only given once at 5 days of age induces virus specific immune response in neonatal mink and protection against virulent CDV exposure later in life.",
keywords = "Faculty of Health and Medical Sciences, Canine distemper virus, Morbillivirus, Neonatal, Mink, Maternal antibodies, DNA vaccination",
author = "Jensen, {Trine Hammer} and Line Nielsen and Bent Aasted and Cino Pertoldi and Merete Blixenkrone-M{\o}ller",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
doi = "10.1016/j.vaccine.2015.01.029",
language = "English",
volume = "33",
pages = "1375--1381",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies

AU - Jensen, Trine Hammer

AU - Nielsen, Line

AU - Aasted, Bent

AU - Pertoldi, Cino

AU - Blixenkrone-Møller, Merete

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Canine distemper virus (CDV) is highly contagious and can cause severe disease against which conventional live vaccines are ineffective in the presence of maternal antibodies. Vaccination in the presences of maternal antibodies was challenged by vaccination of 5 days old and 3 weeks old mink kits with CDV DNA vaccines. Virus neutralising (VN) antibody responses were induced in mink kits vaccinated with a plasmid encoding the haemaglutinin protein (H) of CDV (n=5, pCDV-H) or a combination of the H, fusion (F) and nucleoprotein (N) of CDV (n=5, pCDV-HFN). These DNA vaccinated kits were protected against virulent experimental infection with field strains of CDV. The pCDV-H was more efficient in inducing protective immunity in the presence of maternal antibodies compared to the pCDV-HFN. The results show that DNA vaccination with the pCDV-H or pCDV-HFN (n=4) only given once at 5 days of age induces virus specific immune response in neonatal mink and protection against virulent CDV exposure later in life.

AB - Canine distemper virus (CDV) is highly contagious and can cause severe disease against which conventional live vaccines are ineffective in the presence of maternal antibodies. Vaccination in the presences of maternal antibodies was challenged by vaccination of 5 days old and 3 weeks old mink kits with CDV DNA vaccines. Virus neutralising (VN) antibody responses were induced in mink kits vaccinated with a plasmid encoding the haemaglutinin protein (H) of CDV (n=5, pCDV-H) or a combination of the H, fusion (F) and nucleoprotein (N) of CDV (n=5, pCDV-HFN). These DNA vaccinated kits were protected against virulent experimental infection with field strains of CDV. The pCDV-H was more efficient in inducing protective immunity in the presence of maternal antibodies compared to the pCDV-HFN. The results show that DNA vaccination with the pCDV-H or pCDV-HFN (n=4) only given once at 5 days of age induces virus specific immune response in neonatal mink and protection against virulent CDV exposure later in life.

KW - Faculty of Health and Medical Sciences

KW - Canine distemper virus

KW - Morbillivirus

KW - Neonatal

KW - Mink

KW - Maternal antibodies

KW - DNA vaccination

U2 - 10.1016/j.vaccine.2015.01.029

DO - 10.1016/j.vaccine.2015.01.029

M3 - Journal article

C2 - 25637861

VL - 33

SP - 1375

EP - 1381

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 11

ER -

ID: 132682872