Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxia
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Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasorelaxant peptides. This study examined exercise-induced changes in CGRP and AM levels in 12 healthy sea level natives at sea level (SL) and subsequently after 24 h (HA1) and 5 days (HA5) in high altitude hypoxia (4559 m). Plasma values of CGRP, AM, calcitonin, noradrenaline, adrenaline, lactate and heart rate were measured at rest and during maximal exercise (W(max)). On each study day, the dopamine D(2)-receptor antagonist, domperidone (30 mg; n=6), or no medication (n=6) was given 1 h before exercise. W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. The maximal CGRP levels at W(max) were significantly decreased at HA1 (74.3+/-6.1 pmol/l; p=0.002) and HA5 (69.6+/-6.0 pmol/l; p
Original language | English |
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Journal | Regulatory Peptides |
Volume | 108 |
Issue number | 2-3 |
Pages (from-to) | 89-95 |
Number of pages | 7 |
ISSN | 0167-0115 |
Publication status | Published - 15 Oct 2002 |
- Adrenomedullin, Adult, Altitude, Altitude Sickness, Calcitonin, Calcitonin Gene-Related Peptide, Domperidone, Dopamine Antagonists, Epinephrine, Exercise, Female, Heart Rate, Humans, Lactates, Male, Norepinephrine, Peptides, Reference Values, Vasodilation
Research areas
ID: 47239965