Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

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Standard

Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. / Brakebusch, Cord; Fillatreau, Simon; Potocnik, Alexandre J; Bungartz, Gerd; Wilhelm, Patricia; Svensson, Marcus; Kearney, Phil; Körner, Heinrich; Gray, David; Fässler, Reinhard.

In: Immunity, Vol. 16, No. 3, 2002, p. 465-77.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brakebusch, C, Fillatreau, S, Potocnik, AJ, Bungartz, G, Wilhelm, P, Svensson, M, Kearney, P, Körner, H, Gray, D & Fässler, R 2002, 'Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.', Immunity, vol. 16, no. 3, pp. 465-77.

APA

Brakebusch, C., Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Körner, H., Gray, D., & Fässler, R. (2002). Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity, 16(3), 465-77.

Vancouver

Brakebusch C, Fillatreau S, Potocnik AJ, Bungartz G, Wilhelm P, Svensson M et al. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity. 2002;16(3):465-77.

Author

Brakebusch, Cord ; Fillatreau, Simon ; Potocnik, Alexandre J ; Bungartz, Gerd ; Wilhelm, Patricia ; Svensson, Marcus ; Kearney, Phil ; Körner, Heinrich ; Gray, David ; Fässler, Reinhard. / Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. In: Immunity. 2002 ; Vol. 16, No. 3. pp. 465-77.

Bibtex

@article{37fc5ff0589911dd8d9f000ea68e967b,
title = "Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.",
abstract = "Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.",
author = "Cord Brakebusch and Simon Fillatreau and Potocnik, {Alexandre J} and Gerd Bungartz and Patricia Wilhelm and Marcus Svensson and Phil Kearney and Heinrich K{\"o}rner and David Gray and Reinhard F{\"a}ssler",
note = "Keywords: Animals; Antibody Formation; Antigens, CD29; B-Lymphocytes; Gene Deletion; Gene Expression Regulation; Hematopoiesis; Immunoglobulin M; Mice; T-Lymphocytes",
year = "2002",
language = "English",
volume = "16",
pages = "465--77",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

AU - Brakebusch, Cord

AU - Fillatreau, Simon

AU - Potocnik, Alexandre J

AU - Bungartz, Gerd

AU - Wilhelm, Patricia

AU - Svensson, Marcus

AU - Kearney, Phil

AU - Körner, Heinrich

AU - Gray, David

AU - Fässler, Reinhard

N1 - Keywords: Animals; Antibody Formation; Antigens, CD29; B-Lymphocytes; Gene Deletion; Gene Expression Regulation; Hematopoiesis; Immunoglobulin M; Mice; T-Lymphocytes

PY - 2002

Y1 - 2002

N2 - Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

AB - Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

M3 - Journal article

C2 - 11911830

VL - 16

SP - 465

EP - 477

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 3

ER -

ID: 5141566