BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference. / Hansen, C P; Holstein-Rathlou, N H; Frederiksen, O.

In: Pflügers Archiv: European Journal of Physiology, Vol. 406, No. 5, 1986, p. 497-501.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, CP, Holstein-Rathlou, NH & Frederiksen, O 1986, 'BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference.', Pflügers Archiv: European Journal of Physiology, vol. 406, no. 5, pp. 497-501.

APA

Hansen, C. P., Holstein-Rathlou, N. H., & Frederiksen, O. (1986). BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference. Pflügers Archiv: European Journal of Physiology, 406(5), 497-501.

Vancouver

Hansen CP, Holstein-Rathlou NH, Frederiksen O. BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference. Pflügers Archiv: European Journal of Physiology. 1986;406(5):497-501.

Author

Hansen, C P ; Holstein-Rathlou, N H ; Frederiksen, O. / BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference. In: Pflügers Archiv: European Journal of Physiology. 1986 ; Vol. 406, No. 5. pp. 497-501.

Bibtex

@article{49ed4f20abf111ddb5e9000ea68e967b,
title = "BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference.",
abstract = "The effects of the Ca2+-channel activator BAY K 8644 (a novel dihydropyridine) on transepithelial potential difference (Pd), electrical resistance (Rt), and unidirectional Na+-fluxes were studied in the rabbit gall-bladder. It was observed that BAY K 8644 at concentrations between 10(-7) and 10(-5) M induced regular oscillations in the transepithelial Pd, without affecting the mean value of Pd (or Rt). The mean oscillatory frequency was 18 mHz (approximately 1 cycle per min), and the mean amplitude was 30-35 microV. Oscillations were predominantly elicited from the serosal side. 10(-5) M BAY K 8644 reduced net Na+ -absorption by 16% by inhibiting the mucosa-to-serosa flux. Nifedipine blocked the Pd-oscillations but did not reverse the Na+-transport inhibition. The observed effects of BAY K 8644 are consistent with activation of Ca2+-channels and an increase in intracellular Ca2+-concentration.",
author = "Hansen, {C P} and Holstein-Rathlou, {N H} and O Frederiksen",
note = "Keywords: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Electric Conductivity; Epithelium; Female; Gallbladder; Nifedipine; Rabbits; Sodium",
year = "1986",
language = "English",
volume = "406",
pages = "497--501",
journal = "Pfl{\"u}gers Archiv - European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - BAY K 8644-induced oscillations in rabbit gall-bladder transepithelial potential difference.

AU - Hansen, C P

AU - Holstein-Rathlou, N H

AU - Frederiksen, O

N1 - Keywords: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Electric Conductivity; Epithelium; Female; Gallbladder; Nifedipine; Rabbits; Sodium

PY - 1986

Y1 - 1986

N2 - The effects of the Ca2+-channel activator BAY K 8644 (a novel dihydropyridine) on transepithelial potential difference (Pd), electrical resistance (Rt), and unidirectional Na+-fluxes were studied in the rabbit gall-bladder. It was observed that BAY K 8644 at concentrations between 10(-7) and 10(-5) M induced regular oscillations in the transepithelial Pd, without affecting the mean value of Pd (or Rt). The mean oscillatory frequency was 18 mHz (approximately 1 cycle per min), and the mean amplitude was 30-35 microV. Oscillations were predominantly elicited from the serosal side. 10(-5) M BAY K 8644 reduced net Na+ -absorption by 16% by inhibiting the mucosa-to-serosa flux. Nifedipine blocked the Pd-oscillations but did not reverse the Na+-transport inhibition. The observed effects of BAY K 8644 are consistent with activation of Ca2+-channels and an increase in intracellular Ca2+-concentration.

AB - The effects of the Ca2+-channel activator BAY K 8644 (a novel dihydropyridine) on transepithelial potential difference (Pd), electrical resistance (Rt), and unidirectional Na+-fluxes were studied in the rabbit gall-bladder. It was observed that BAY K 8644 at concentrations between 10(-7) and 10(-5) M induced regular oscillations in the transepithelial Pd, without affecting the mean value of Pd (or Rt). The mean oscillatory frequency was 18 mHz (approximately 1 cycle per min), and the mean amplitude was 30-35 microV. Oscillations were predominantly elicited from the serosal side. 10(-5) M BAY K 8644 reduced net Na+ -absorption by 16% by inhibiting the mucosa-to-serosa flux. Nifedipine blocked the Pd-oscillations but did not reverse the Na+-transport inhibition. The observed effects of BAY K 8644 are consistent with activation of Ca2+-channels and an increase in intracellular Ca2+-concentration.

M3 - Journal article

C2 - 2423958

VL - 406

SP - 497

EP - 501

JO - Pflügers Archiv - European Journal of Physiology

JF - Pflügers Archiv - European Journal of Physiology

SN - 0031-6768

IS - 5

ER -

ID: 8440391