9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage
Research output: Contribution to journal › Journal article › Research › peer-review
The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.
| Original language | English |
|---|---|
| Journal | International Journal of Peptide and Protein Research |
| Volume | 32 |
| Issue number | 5 |
| Pages (from-to) | 331-343 |
| Number of pages | 13 |
| ISSN | 0367-8377 |
| Publication status | Published - Nov 1988 |
- Acridines/chemical synthesis, Amino Acid Sequence, Chemical Phenomena, Chemistry, DNA/drug effects, Molecular Sequence Data, Molecular Structure, Nitrobenzenes/chemical synthesis, Peptides/chemical synthesis, Photochemistry, Sulfones/chemical synthesis
Research areas
ID: 203631170