9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage. / Karup, G; Meldal, M; Nielsen, Peter E.; Buchardt, O.

In: International Journal of Peptide and Protein Research, Vol. 32, No. 5, 11.1988, p. 331-343.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Karup, G, Meldal, M, Nielsen, PE & Buchardt, O 1988, '9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage', International Journal of Peptide and Protein Research, vol. 32, no. 5, pp. 331-343.

APA

Karup, G., Meldal, M., Nielsen, P. E., & Buchardt, O. (1988). 9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage. International Journal of Peptide and Protein Research, 32(5), 331-343.

Vancouver

Karup G, Meldal M, Nielsen PE, Buchardt O. 9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage. International Journal of Peptide and Protein Research. 1988 Nov;32(5):331-343.

Author

Karup, G ; Meldal, M ; Nielsen, Peter E. ; Buchardt, O. / 9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage. In: International Journal of Peptide and Protein Research. 1988 ; Vol. 32, No. 5. pp. 331-343.

Bibtex

@article{afc120d14de3456abc183e844bbaebaf,
title = "9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage",
abstract = "The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in {"}photonuclease{"} activity of some of the modified peptides.",
keywords = "Acridines/chemical synthesis, Amino Acid Sequence, Chemical Phenomena, Chemistry, DNA/drug effects, Molecular Sequence Data, Molecular Structure, Nitrobenzenes/chemical synthesis, Peptides/chemical synthesis, Photochemistry, Sulfones/chemical synthesis",
author = "G Karup and M Meldal and Nielsen, {Peter E.} and O Buchardt",
year = "1988",
month = nov,
language = "English",
volume = "32",
pages = "331--343",
journal = "International journal of protein research",
issn = "0367-8377",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - 9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage

AU - Karup, G

AU - Meldal, M

AU - Nielsen, Peter E.

AU - Buchardt, O

PY - 1988/11

Y1 - 1988/11

N2 - The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.

AB - The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.

KW - Acridines/chemical synthesis

KW - Amino Acid Sequence

KW - Chemical Phenomena

KW - Chemistry

KW - DNA/drug effects

KW - Molecular Sequence Data

KW - Molecular Structure

KW - Nitrobenzenes/chemical synthesis

KW - Peptides/chemical synthesis

KW - Photochemistry

KW - Sulfones/chemical synthesis

M3 - Journal article

C2 - 3209353

VL - 32

SP - 331

EP - 343

JO - International journal of protein research

JF - International journal of protein research

SN - 0367-8377

IS - 5

ER -

ID: 203631170