As recently detailed in the The Lancet, drug-resistant bacteria kill 1.27m people annually, more than HIV and malaria combined. Deaths are disproportionately concentrated in low- and middle-income countries, especially in children under 5 years old. Sustainable Development Goals are threatened by this ongoing toll. It is evident that determined and well-coordinated international actions are needed to tackle this global health threat from a One Health perspective. While antimicrobial resistance (AMR) is often seen as a technical issue of drug development, solutions to this problem will require serious engagement with those working in the social sciences. Hence, this Workshop. Two key international developments could help to meet this grand challenge: (1) negotiations for a Pandemic Treaty that includes policies to manage AMR; and (2) establishing the Independent Panel on Evidence for Action on AMR (IPEA). Both stand to address the clear need for international and interdisciplinary collaboration on AMR policy and action. To maximise early success, we propose collective orientation of the scholarly community – in particular the social sciences – towards establishing a coherent evidence base to guide international and national efforts to stem AMR and its impact.