Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications
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Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications. / Weischendorff, Sarah; Kielsen, Katrine; Nederby, Maria; Schmidt, Lotte; Burrin, Douglas; Heilmann, Carsten; Ifversen, Marianne; Sengeløv, Henrik; Mølgaard, Christian; Müller, Klaus.
In: Biology of Blood and Marrow Transplantation, Vol. 25, No. 7, 2019, p. 1432-1440.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications
AU - Weischendorff, Sarah
AU - Kielsen, Katrine
AU - Nederby, Maria
AU - Schmidt, Lotte
AU - Burrin, Douglas
AU - Heilmann, Carsten
AU - Ifversen, Marianne
AU - Sengeløv, Henrik
AU - Mølgaard, Christian
AU - Müller, Klaus
N1 - CURIS 2019 NEXS 138 Copyright © 2019. Published by Elsevier Inc.
PY - 2019
Y1 - 2019
N2 - Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) are challenged by cytotoxic effects of the conditioning regimen, resulting in tissue damage, systemic inflammation and elevated metabolic demands for amino acids to regenerate damaged tissues, reconstitute hematopoietic cells, and establish antioxidant defenses. Few studies have addressed the role of plasma amino acid (PAA) levels during transplantation, and it remains unknown if amino acid deficiency can aggravate treatment-related morbidity. We determined plasma levels of the 23 human amino acids in 80 HSCT patients (age 1.1-55.4 years) before conditioning and on day +7 and +21 post-transplant along with C-reactive protein (CRP) and Interleukin 6 (IL-6) levels on day +7. Significant changes were observed in plasma concentrations of several human amino acids during HSCT. On day +7, several amino acids were inversely correlated with both CRP and IL-6, including glutamic acid, serine, alanine, glutamine, arginine, cysteine, glycine, histidine, lysine, tryptophan, threonine, taurine, proline, and methionine (r between -0.22 and -0.66, all p<0.05). Patients developing sinusoidal obstruction syndrome (SOS) had significantly lower total PAA levels compared to patients without SOS (2013 ng/l (1709-2318) vs 2706 ng/l (2261-3150), p=0.006) along with lower individual levels of glutamic acid, serine, arginine, glycine, lysine, valine, tryptophan, threonine, and proline (all p<0.05) on day +7. Patients with severe acute graft-versus-host disease had lower total PAA level (1922 ng/l (1738-2106) vs 2649 ng/l (2244-3055), p=0.014) and decreased levels of serine, glutamine, cysteine, glycine, lysine and threonine on day +7 (all p<0.05). These results indicate a relationship between low concentrations of certain amino acids and risk of treatment-related complications.
AB - Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) are challenged by cytotoxic effects of the conditioning regimen, resulting in tissue damage, systemic inflammation and elevated metabolic demands for amino acids to regenerate damaged tissues, reconstitute hematopoietic cells, and establish antioxidant defenses. Few studies have addressed the role of plasma amino acid (PAA) levels during transplantation, and it remains unknown if amino acid deficiency can aggravate treatment-related morbidity. We determined plasma levels of the 23 human amino acids in 80 HSCT patients (age 1.1-55.4 years) before conditioning and on day +7 and +21 post-transplant along with C-reactive protein (CRP) and Interleukin 6 (IL-6) levels on day +7. Significant changes were observed in plasma concentrations of several human amino acids during HSCT. On day +7, several amino acids were inversely correlated with both CRP and IL-6, including glutamic acid, serine, alanine, glutamine, arginine, cysteine, glycine, histidine, lysine, tryptophan, threonine, taurine, proline, and methionine (r between -0.22 and -0.66, all p<0.05). Patients developing sinusoidal obstruction syndrome (SOS) had significantly lower total PAA levels compared to patients without SOS (2013 ng/l (1709-2318) vs 2706 ng/l (2261-3150), p=0.006) along with lower individual levels of glutamic acid, serine, arginine, glycine, lysine, valine, tryptophan, threonine, and proline (all p<0.05) on day +7. Patients with severe acute graft-versus-host disease had lower total PAA level (1922 ng/l (1738-2106) vs 2649 ng/l (2244-3055), p=0.014) and decreased levels of serine, glutamine, cysteine, glycine, lysine and threonine on day +7 (all p<0.05). These results indicate a relationship between low concentrations of certain amino acids and risk of treatment-related complications.
KW - Faculty of Science
KW - Hematopoietic stem cell transplantation
KW - Amino acids
KW - Systemic inflammation
KW - Sinusoidal obstruction syndrome
KW - Acute graft-versus-host disease
U2 - 10.1016/j.bbmt.2019.03.018
DO - 10.1016/j.bbmt.2019.03.018
M3 - Journal article
C2 - 30910606
VL - 25
SP - 1432
EP - 1440
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 7
ER -
ID: 215506960