Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial. / Schmidt, Rikke Meineche; Laursen, Rikke Pilmann; Bruun, Signe; Larnkjær, Anni; Mølgaard, Christian; Michaelsen, Kim F.; Høst, Arne.
In: Pediatric Allergy and Immunology, Vol. 30, No. 3, 2019, p. 335-340.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial
AU - Schmidt, Rikke Meineche
AU - Laursen, Rikke Pilmann
AU - Bruun, Signe
AU - Larnkjær, Anni
AU - Mølgaard, Christian
AU - Michaelsen, Kim F.
AU - Høst, Arne
N1 - CURIS 2019 NEXS 070 © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2019
Y1 - 2019
N2 - Background: Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization.Methods: In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo-starting prior to attending day care. The intervention period was 6 months, and the parents answered web-based questionnaires on allergic symptoms and doctor's diagnosed allergic disease monthly. IgE was measured at baseline and follow-up.Results: A total of 290 participants were randomized: 144 in the probiotic group and 146 in the placebo group. Mean age at intervention start was 10.1 months. At follow-up (mean age 16.1 months), the incidence of eczema was 4.2% in the probiotic group and 11.5% in the placebo group (P = 0.036). The incidence of asthma and conjunctivitis did not differ between groups, and no children presented with rhinitis. Sensitization was equal in the two groups at intervention start (7.5% and 9.5%, respectively), and two children in each group were sensitized during the intervention.Conclusions: We observed a significantly lower incidence of eczema in the probiotic group compared to the placebo group. The probiotics were administered in late infancy-prior to attending day care-suggesting a broader window of opportunity using probiotics in the prevention of eczema. The incidence of asthma, rhinitis, conjunctivitis, and sensitization did not differ.
AB - Background: Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization.Methods: In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo-starting prior to attending day care. The intervention period was 6 months, and the parents answered web-based questionnaires on allergic symptoms and doctor's diagnosed allergic disease monthly. IgE was measured at baseline and follow-up.Results: A total of 290 participants were randomized: 144 in the probiotic group and 146 in the placebo group. Mean age at intervention start was 10.1 months. At follow-up (mean age 16.1 months), the incidence of eczema was 4.2% in the probiotic group and 11.5% in the placebo group (P = 0.036). The incidence of asthma and conjunctivitis did not differ between groups, and no children presented with rhinitis. Sensitization was equal in the two groups at intervention start (7.5% and 9.5%, respectively), and two children in each group were sensitized during the intervention.Conclusions: We observed a significantly lower incidence of eczema in the probiotic group compared to the placebo group. The probiotics were administered in late infancy-prior to attending day care-suggesting a broader window of opportunity using probiotics in the prevention of eczema. The incidence of asthma, rhinitis, conjunctivitis, and sensitization did not differ.
KW - Faculty of Science
KW - Allergic diseases
KW - Allergy
KW - Atopy
KW - Bifidobacterium animalis subsp lactis
KW - Lactobacillus rhamnosus
KW - RCT
KW - Sensitization
U2 - 10.1111/pai.13018
DO - 10.1111/pai.13018
M3 - Journal article
C2 - 30790361
VL - 30
SP - 335
EP - 340
JO - Pediatric Allergy and Immunology, Supplement
JF - Pediatric Allergy and Immunology, Supplement
SN - 0906-5784
IS - 3
ER -
ID: 213854377