Occurrence of thymosin ß4 in human breast cancer cells and in other cell types of the tumor microenvironment
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Occurrence of thymosin ß4 in human breast cancer cells and in other cell types of the tumor microenvironment. / Larsson, Lars-Inge; Holck, Susanne.
In: Human Pathology, Vol. 38, No. 1, 2007, p. 114-119.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Occurrence of thymosin ß4 in human breast cancer cells and in other cell types of the tumor microenvironment
AU - Larsson, Lars-Inge
AU - Holck, Susanne
PY - 2007
Y1 - 2007
N2 - Previous studies have shown that the G-actin sequestering polypeptide thymosin ß4 frequently is overexpressed in cancers and that such overexpression correlates to malignant progression. However, the localization of thymosin ß4 in human cancers has not been determined. We now demonstrate that there is a considerable heterogeneity in the cellular distribution of thymosin ß4 in breast cancer. In most tumors examined, cancer cells showed low or intermediate reactivity for thymosin ß4, whereas leukocytes and macrophages showed intense reactivity. In addition, endothelial cells showed variable reactivity to thymosin ß4, whereas myofibroblasts were negative. There was no correlation between the intensity of tumor cell staining and histological grade, whereas there was a tendency toward a correlation between endothelial cell staining and grade. These results demonstrate that multiple cell types within the tumor microenvironment produce thymosin ß4 and that such expression varies from tumor to tumor. Such heterogeneity of expression should be taken into account when the role of thymosin ß4 in tumor biology is assessed.
AB - Previous studies have shown that the G-actin sequestering polypeptide thymosin ß4 frequently is overexpressed in cancers and that such overexpression correlates to malignant progression. However, the localization of thymosin ß4 in human cancers has not been determined. We now demonstrate that there is a considerable heterogeneity in the cellular distribution of thymosin ß4 in breast cancer. In most tumors examined, cancer cells showed low or intermediate reactivity for thymosin ß4, whereas leukocytes and macrophages showed intense reactivity. In addition, endothelial cells showed variable reactivity to thymosin ß4, whereas myofibroblasts were negative. There was no correlation between the intensity of tumor cell staining and histological grade, whereas there was a tendency toward a correlation between endothelial cell staining and grade. These results demonstrate that multiple cell types within the tumor microenvironment produce thymosin ß4 and that such expression varies from tumor to tumor. Such heterogeneity of expression should be taken into account when the role of thymosin ß4 in tumor biology is assessed.
KW - Former LIFE faculty
KW - Thymosin
KW - Breast cancer
KW - Macrophages
KW - Endothelial cells
KW - Biomarkers
U2 - 10.1016/j.humpath.2006.06.025
DO - 10.1016/j.humpath.2006.06.025
M3 - Journal article
C2 - 16949646
VL - 38
SP - 114
EP - 119
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 1
ER -
ID: 8045351