Modulation of fronto-parietal connections during the rubber hand illusion
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Modulation of fronto-parietal connections during the rubber hand illusion. / Karabanov, Anke Ninija; Ritterband-Rosenbaum, Anina; Christensen, Mark Schram; Siebner, Hartwig Roman; Nielsen, Jens Bo.
In: European Journal of Neuroscience, Vol. 45, No. 7, 2017, p. 964-974.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modulation of fronto-parietal connections during the rubber hand illusion
AU - Karabanov, Anke Ninija
AU - Ritterband-Rosenbaum, Anina
AU - Christensen, Mark Schram
AU - Siebner, Hartwig Roman
AU - Nielsen, Jens Bo
N1 - CURIS 2017 NEXS 084
PY - 2017
Y1 - 2017
N2 - Accumulating evidence suggests that parieto-frontal connections play a role in adjusting body ownership during the Rubber Hand Illusion (RHI). Using a motor version of the rubber hand illusion paradigm, we applied single-site and dual-site transcranial magnetic stimulation (TMS) to investigate cortico-spinal and parietal-frontal connectivity during perceived rubber hand ownership. Healthy volunteers received a conditioning TMS pulse over left anterior intraparietal sulcus (aIPS) and a test TMS pulse over left primary motor cortex (M1). Motor Evoked Potentials (MEPs) were recorded at rest and during three RHI conditions: a) agency and ownership, b) agency but no ownership and c) neither agency nor ownership. Parietal-motor communication differed among experimental conditions. The induction of action ownership was associated with an inhibitory parietal-to-motor connectivity, which was comparable to the aIPS-to-M1 inhibition present at rest. This aIPS-to-M1 inhibition disappeared during movement conditions not inducing ownership. Cortico-spinal excitability was not significantly modulated during the motor RHI as indicated by the task-constant MEP amplitude elicited by the M1 test pulse alone. Our results indicate that the perceived ownership over the rubber hand is associated with normal parietal-motor communication. This communication is disturbed if the sensorimotor conflict between one's own hand and the rubber hand is not resolved. This article is protected by copyright. All rights reserved.
AB - Accumulating evidence suggests that parieto-frontal connections play a role in adjusting body ownership during the Rubber Hand Illusion (RHI). Using a motor version of the rubber hand illusion paradigm, we applied single-site and dual-site transcranial magnetic stimulation (TMS) to investigate cortico-spinal and parietal-frontal connectivity during perceived rubber hand ownership. Healthy volunteers received a conditioning TMS pulse over left anterior intraparietal sulcus (aIPS) and a test TMS pulse over left primary motor cortex (M1). Motor Evoked Potentials (MEPs) were recorded at rest and during three RHI conditions: a) agency and ownership, b) agency but no ownership and c) neither agency nor ownership. Parietal-motor communication differed among experimental conditions. The induction of action ownership was associated with an inhibitory parietal-to-motor connectivity, which was comparable to the aIPS-to-M1 inhibition present at rest. This aIPS-to-M1 inhibition disappeared during movement conditions not inducing ownership. Cortico-spinal excitability was not significantly modulated during the motor RHI as indicated by the task-constant MEP amplitude elicited by the M1 test pulse alone. Our results indicate that the perceived ownership over the rubber hand is associated with normal parietal-motor communication. This communication is disturbed if the sensorimotor conflict between one's own hand and the rubber hand is not resolved. This article is protected by copyright. All rights reserved.
KW - Faculty of Science
KW - Anterior intraparietal sulcus
KW - Body ownership
KW - Paired-pulse TMS
KW - Primary motor cortex
KW - Sensory-motor mismatch
U2 - 10.1111/ejn.13538
DO - 10.1111/ejn.13538
M3 - Journal article
C2 - 28186673
VL - 45
SP - 964
EP - 974
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 7
ER -
ID: 173252548