Interactions between insulin and exercise
Research output: Contribution to journal › Review › Research › peer-review
Standard
Interactions between insulin and exercise. / Richter, Erik A.; Sylow, Lykke; Hargreaves, Mark.
In: Biochemical Journal, Vol. 478, No. 21, 2021, p. 3827-3846.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Interactions between insulin and exercise
AU - Richter, Erik A.
AU - Sylow, Lykke
AU - Hargreaves, Mark
N1 - © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
PY - 2021
Y1 - 2021
N2 - The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regulatory forces under varying conditions. While insulin is secreted after food intake and is the primary hormone increasing glucose storage as glycogen and fatty acid storage as triglycerides, exercise is a condition where fuel stores need to be mobilized and oxidized. Thus, during physical activity the fuel storage effects of insulin need to be suppressed. This is done primarily by inhibiting insulin secretion during exercise as well as activating local and systemic fuel mobilizing processes. In contrast, following exercise there is a need for refilling the fuel depots mobilized during exercise, particularly the glycogen stores in muscle. This process is facilitated by an increase in insulin sensitivity of the muscles previously engaged in physical activity which directs glucose to glycogen resynthesis. In physically trained individuals, insulin sensitivity is also higher than in untrained individuals due to adaptations in the vasculature, skeletal muscle and adipose tissue. In this paper, we review the interactions between insulin and exercise during and after exercise, as well as the effects of regular exercise training on insulin action.
AB - The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regulatory forces under varying conditions. While insulin is secreted after food intake and is the primary hormone increasing glucose storage as glycogen and fatty acid storage as triglycerides, exercise is a condition where fuel stores need to be mobilized and oxidized. Thus, during physical activity the fuel storage effects of insulin need to be suppressed. This is done primarily by inhibiting insulin secretion during exercise as well as activating local and systemic fuel mobilizing processes. In contrast, following exercise there is a need for refilling the fuel depots mobilized during exercise, particularly the glycogen stores in muscle. This process is facilitated by an increase in insulin sensitivity of the muscles previously engaged in physical activity which directs glucose to glycogen resynthesis. In physically trained individuals, insulin sensitivity is also higher than in untrained individuals due to adaptations in the vasculature, skeletal muscle and adipose tissue. In this paper, we review the interactions between insulin and exercise during and after exercise, as well as the effects of regular exercise training on insulin action.
KW - Faculty of Science
KW - Exercise
KW - Glucose uptake
KW - Insulin
KW - Insulin sensitivity
KW - Muscle metabolism
KW - Physical activity
U2 - 10.1042/BCJ20210185
DO - 10.1042/BCJ20210185
M3 - Review
C2 - 34751700
VL - 478
SP - 3827
EP - 3846
JO - Biochemical Journal
JF - Biochemical Journal
SN - 0264-6021
IS - 21
ER -
ID: 284404703