Hypoxic training improves normoxic glucose tolerance in adolescents with obesity
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Hypoxic training improves normoxic glucose tolerance in adolescents with obesity. / De Groote, Estelle; Britto, Florian A; Bullock, Loïc; François, Marie; De Buck, Carine; Nielens, Henri; Deldicque, Louise.
In: Medicine and Science in Sports and Exercise, Vol. 50, No. 11, 2018, p. 2200-2208.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hypoxic training improves normoxic glucose tolerance in adolescents with obesity
AU - De Groote, Estelle
AU - Britto, Florian A
AU - Bullock, Loïc
AU - François, Marie
AU - De Buck, Carine
AU - Nielens, Henri
AU - Deldicque, Louise
N1 - (Ekstern)
PY - 2018
Y1 - 2018
N2 - Purpose: This study aimed to test whether environmental hypoxia could potentiate the effects of exercise training on glucose metabolism and insulin sensitivity.Methods: Fourteen adolescents with obesity were assigned to 6 wk of exercise training either in normoxic or in hypoxic conditions (FiO2 15%). Adolescents trained three times per week for 50-60 min, including endurance and resistance exercises. Oral glucose tolerance test, blood and morphological analyses, and physical performance tests were performed before and after the training period.Results: After training, hypoxia, but not normoxia, decreased the area under the curve of plasma insulin (-49%; P = 0.001) and glucose levels (-14%; P = 0.005) during oral glucose tolerance test. Decreased plasma triglycerides levels (P = 0.03) and increased maximal aerobic power (P = 0.002), work capacity at 160 bpm (P = 0.002), and carbohydrate consumption during exercise (P = 0.03) were measured only in the hypoxic group.Conclusions: Hypoxic exercise training was particularly efficient at improving glucose tolerance and insulin response to a glucose challenge in adolescents with obesity. These results suggest that exercise training in hypoxia could be an interesting strategy against insulin resistance and type 2 diabetes development in adolescents with obesity.
AB - Purpose: This study aimed to test whether environmental hypoxia could potentiate the effects of exercise training on glucose metabolism and insulin sensitivity.Methods: Fourteen adolescents with obesity were assigned to 6 wk of exercise training either in normoxic or in hypoxic conditions (FiO2 15%). Adolescents trained three times per week for 50-60 min, including endurance and resistance exercises. Oral glucose tolerance test, blood and morphological analyses, and physical performance tests were performed before and after the training period.Results: After training, hypoxia, but not normoxia, decreased the area under the curve of plasma insulin (-49%; P = 0.001) and glucose levels (-14%; P = 0.005) during oral glucose tolerance test. Decreased plasma triglycerides levels (P = 0.03) and increased maximal aerobic power (P = 0.002), work capacity at 160 bpm (P = 0.002), and carbohydrate consumption during exercise (P = 0.03) were measured only in the hypoxic group.Conclusions: Hypoxic exercise training was particularly efficient at improving glucose tolerance and insulin response to a glucose challenge in adolescents with obesity. These results suggest that exercise training in hypoxia could be an interesting strategy against insulin resistance and type 2 diabetes development in adolescents with obesity.
KW - Faculty of Science
KW - Insulin resistance
KW - Hypoxia
KW - Physical activity
KW - Glucose metabolism
U2 - 10.1249/MSS.0000000000001694
DO - 10.1249/MSS.0000000000001694
M3 - Journal article
C2 - 29923910
VL - 50
SP - 2200
EP - 2208
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 11
ER -
ID: 214128634