Effectiveness of a locally produced, fish-based food product on weight gain among Cambodian children in the treatment of acute malnutrition: A randomized controlled trial
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Effectiveness of a locally produced, fish-based food product on weight gain among Cambodian children in the treatment of acute malnutrition : A randomized controlled trial. / Sigh, Sanne; Roos, Nanna; Chamnan, Chhoun; Laillou, Arnaud; Prak, Sophanneary; Wieringa, Frank T.
In: Nutrients, Vol. 10, No. 7, 909, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effectiveness of a locally produced, fish-based food product on weight gain among Cambodian children in the treatment of acute malnutrition
T2 - A randomized controlled trial
AU - Sigh, Sanne
AU - Roos, Nanna
AU - Chamnan, Chhoun
AU - Laillou, Arnaud
AU - Prak, Sophanneary
AU - Wieringa, Frank T
N1 - CURIS 2018 NEXS 246
PY - 2018
Y1 - 2018
N2 - Cambodia continues to have a high prevalence of acute malnutrition. Low acceptability has been found for standard ready-to-use-therapeutic-food (RUTF) products. Therefore, NumTrey, a locally-produced fish-based RUTF, was developed. The objective was to evaluate the effectiveness of NumTrey compared to an imported milk-based RUTF for weight gain among children aged 6⁻59 months in the home-treatment for acute malnutrition. Effectiveness was tested in a single-blinded randomized controlled trial with weight gain as the primary outcome. Anthropometry was assessed at baseline and bi-weekly follow-ups until endline at Week 8. In total, 121 patients were randomized into BP-100TM (n = 61) or NumTrey (n = 60). There was no statistical difference in mean weight gain between the groups (1.06 g/kg/day; 95% CI (0.72, 1.41) and 1.08 g/kg/day; 95% CI (0.75, 1.41) for BP-100™ and NumTrey, respectively). In addition, no statistically significant differences in secondary outcomes were found. Although the ability to draw conclusions was limited by lower weight gain than the desired 4 g/kg/day in both groups, no superiority was found for eitherRUTF. A locally produced RUTF is highly relevant to improve nutrition interventions in Cambodia. A locally produced fish-based RUTF is a relevant alternative to imported milk-based RUTF for the treatment of SAM in Cambodia.
AB - Cambodia continues to have a high prevalence of acute malnutrition. Low acceptability has been found for standard ready-to-use-therapeutic-food (RUTF) products. Therefore, NumTrey, a locally-produced fish-based RUTF, was developed. The objective was to evaluate the effectiveness of NumTrey compared to an imported milk-based RUTF for weight gain among children aged 6⁻59 months in the home-treatment for acute malnutrition. Effectiveness was tested in a single-blinded randomized controlled trial with weight gain as the primary outcome. Anthropometry was assessed at baseline and bi-weekly follow-ups until endline at Week 8. In total, 121 patients were randomized into BP-100TM (n = 61) or NumTrey (n = 60). There was no statistical difference in mean weight gain between the groups (1.06 g/kg/day; 95% CI (0.72, 1.41) and 1.08 g/kg/day; 95% CI (0.75, 1.41) for BP-100™ and NumTrey, respectively). In addition, no statistically significant differences in secondary outcomes were found. Although the ability to draw conclusions was limited by lower weight gain than the desired 4 g/kg/day in both groups, no superiority was found for eitherRUTF. A locally produced RUTF is highly relevant to improve nutrition interventions in Cambodia. A locally produced fish-based RUTF is a relevant alternative to imported milk-based RUTF for the treatment of SAM in Cambodia.
KW - Faculty of Science
KW - Severe acute malnutrition
KW - Fish
KW - Ready-to-use therapeutic food
KW - Effectiveness
KW - Weight gain
KW - Cambodia
U2 - 10.3390/nu10070909
DO - 10.3390/nu10070909
M3 - Journal article
C2 - 30012981
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 7
M1 - 909
ER -
ID: 200337946