Prevotella abundance predicts weight loss success in healthy, overweight adults consuming a whole-grain diet ad libitum: A post hoc analysis of a 6-wk randomized controlled trial
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Prevotella abundance predicts weight loss success in healthy, overweight adults consuming a whole-grain diet ad libitum : A post hoc analysis of a 6-wk randomized controlled trial. / Christensen, Lars; Vuholm, Stine; Roager, Henrik Munch; Nielsen, Dennis Sandris; Krych, Lukasz; Kristensen, Mette Bredal; Astrup, Arne; Hjorth, Mads Fiil.
In: Journal of Nutrition, Vol. 149, No. 12, 2019, p. 2174-2181.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prevotella abundance predicts weight loss success in healthy, overweight adults consuming a whole-grain diet ad libitum
T2 - A post hoc analysis of a 6-wk randomized controlled trial
AU - Christensen, Lars
AU - Vuholm, Stine
AU - Roager, Henrik Munch
AU - Nielsen, Dennis Sandris
AU - Krych, Lukasz
AU - Kristensen, Mette Bredal
AU - Astrup, Arne
AU - Hjorth, Mads Fiil
N1 - CURIS 2019 NEXS 279
PY - 2019
Y1 - 2019
N2 - Background: The key to effective weight loss may be to match diet and gut microbes, since recent studies have found that subjects with high Prevotella abundances in their gut microbiota losemore weight on diets rich in fiber than subjects with low Prevotella abundances.Objectives: We reanalyzed a 6-wk, parallel, randomized trial to investigate difference in body weight changes when participants, stratified by fecal microbiota composition, consumed ad libitum a whole-grain (WG) or a refined-wheat (RW) diet.Methods: We stratified 46 (19 men, 27 women; ages 30–65 y) healthy, overweight adults by baseline Prevotella-to-Bacteroides ratios and Prevotella abundances. Subjects with no Prevotella were analyzed separately (n = 24). Compared with the RW diet (mean = 221 g/d), the WG diet (mean = 228 g/d) had a higher fiber content (33 g/d compared with 23 g/d). Linear mixed models and correlations were applied to link 6-wk changes in body weights and metabolic and microbiota markers, according to Prevotella groups and diets.Results: The Prevotella abundances correlated inversely with weight changes (r = −0.34; P = 0.043). Consequently, subjects with high Prevotella abundances (n = 15) spontaneously lost 1.80 kg (95% CI: −3.23, −0.37 kg; P = 0.013) moreon theWG diet than on the RWdiet, whereas those with low Prevotella abundances (n = 31) were weight stable (−0.22 kg; 95% CI: −1.40, 0.96 kg; P = 0.72). Thus, the mean difference between the Prevotella groups was 2.02 kg (95% CI: −3.87, −0.17 kg; P = 0.032). Subjects with no Prevotella lost 1.59 kg (95% CI: −2.65, −0.52 kg; P = 0.004) more on the WG diet than on the RW diet. No 6-wk changes in appetite sensations, glucose metabolisms, or fecal SCFAs were associated with the Prevotella groups.Conclusions: Healthy, overweight adults with high Prevotella abundances lost more weight than subjects with low Prevotella abundances when consuming a diet rich in WG and fiber ad libitum for 6 wk. This further supports enterotypesas a potential biomarker in personalized nutrition for obesity management. This trial was registered at clinicaltrials.gov as NCT02358122.
AB - Background: The key to effective weight loss may be to match diet and gut microbes, since recent studies have found that subjects with high Prevotella abundances in their gut microbiota losemore weight on diets rich in fiber than subjects with low Prevotella abundances.Objectives: We reanalyzed a 6-wk, parallel, randomized trial to investigate difference in body weight changes when participants, stratified by fecal microbiota composition, consumed ad libitum a whole-grain (WG) or a refined-wheat (RW) diet.Methods: We stratified 46 (19 men, 27 women; ages 30–65 y) healthy, overweight adults by baseline Prevotella-to-Bacteroides ratios and Prevotella abundances. Subjects with no Prevotella were analyzed separately (n = 24). Compared with the RW diet (mean = 221 g/d), the WG diet (mean = 228 g/d) had a higher fiber content (33 g/d compared with 23 g/d). Linear mixed models and correlations were applied to link 6-wk changes in body weights and metabolic and microbiota markers, according to Prevotella groups and diets.Results: The Prevotella abundances correlated inversely with weight changes (r = −0.34; P = 0.043). Consequently, subjects with high Prevotella abundances (n = 15) spontaneously lost 1.80 kg (95% CI: −3.23, −0.37 kg; P = 0.013) moreon theWG diet than on the RWdiet, whereas those with low Prevotella abundances (n = 31) were weight stable (−0.22 kg; 95% CI: −1.40, 0.96 kg; P = 0.72). Thus, the mean difference between the Prevotella groups was 2.02 kg (95% CI: −3.87, −0.17 kg; P = 0.032). Subjects with no Prevotella lost 1.59 kg (95% CI: −2.65, −0.52 kg; P = 0.004) more on the WG diet than on the RW diet. No 6-wk changes in appetite sensations, glucose metabolisms, or fecal SCFAs were associated with the Prevotella groups.Conclusions: Healthy, overweight adults with high Prevotella abundances lost more weight than subjects with low Prevotella abundances when consuming a diet rich in WG and fiber ad libitum for 6 wk. This further supports enterotypesas a potential biomarker in personalized nutrition for obesity management. This trial was registered at clinicaltrials.gov as NCT02358122.
KW - Faculty of Science
KW - Weight loss
KW - Overweight
KW - Obesity
KW - Enterotype
KW - Prevotella
KW - Whole grain
KW - Fiber
KW - Gut microbiota
U2 - 10.1093/jn/nxz198
DO - 10.1093/jn/nxz198
M3 - Journal article
C2 - 31504699
VL - 149
SP - 2174
EP - 2181
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 12
ER -
ID: 226878552