Preserved capacity for adaptations in strength and muscle regulatory factors in elderly in response to resistance exercise training and deconditioning
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Fritzen et al_Journal of Clinical Medicine_2020_Vol 9(7)_e2188
Final published version, 1.61 MB, PDF document
Aging is related to an inevitable loss of muscle mass and strength. The mechanisms behind age-related loss of muscle tissue are not fully understood but may, among other things, be induced by age-related differences in myogenic regulatory factors. Resistance exercise training and deconditioning offers a model to investigate differences in myogenic regulatory factors that may be important for age-related loss of muscle mass and strength. Nine elderly (82 ± 7 years old) and nine young, healthy persons (22 ± 2 years old) participated in the study. Exercise consisted of six weeks of resistance training of the quadriceps muscle followed by eight weeks of deconditioning. Muscle biopsy samples before and after training and during the deconditioning period were analyzed for MyoD, myogenin, insulin-like growth-factor I receptor, activin receptor IIB, smad2, porin, and citrate synthase. Muscle strength improved with resistance training by 78% (95.0 ± 22.0 kg) in the elderly to a similar extent as in the young participants (83.5%; 178.2 ± 44.2 kg) and returned to baseline in both groups after eight weeks of deconditioning. No difference was seen in expression of muscle regulatory factors between elderly and young in response to exercise training and deconditioning. In conclusion, the capacity to gain muscle strength with resistance exercise training in elderly was not impaired, highlighting this as a potent tool to combat age-related loss of muscle function, possibly due to preserved regulation of myogenic factors in elderly compared with young muscle.
Original language | English |
---|---|
Article number | 2188 |
Journal | Journal of Clinical Medicine |
Volume | 9 |
Issue number | 7 |
Number of pages | 15 |
ISSN | 2077-0383 |
DOIs | |
Publication status | Published - 2020 |
- Faculty of Science - Resistance exercise training, Muscle regulatory factors, Sarcopenia, Muscle strength, Deconditioning, Skeletal muscle, Elderly, Hypertrophy
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 245235389