Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection. / Chen, Xueli; Lin, Mingquan; Cui, He; Chen, Yimin; van Engelen, Arna; de Bruijne, Marleen; Azarpazhooh, M Reza; Sohrevardi, Seyed Mojtaba; Chow, Tommy W S; Spence, J David; Chiu, Bernard.

In: Computer Methods and Programs in Biomedicine, Vol. 184, 105276, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chen, X, Lin, M, Cui, H, Chen, Y, van Engelen, A, de Bruijne, M, Azarpazhooh, MR, Sohrevardi, SM, Chow, TWS, Spence, JD & Chiu, B 2020, 'Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection', Computer Methods and Programs in Biomedicine, vol. 184, 105276. https://doi.org/10.1016/j.cmpb.2019.105276

APA

Chen, X., Lin, M., Cui, H., Chen, Y., van Engelen, A., de Bruijne, M., Azarpazhooh, M. R., Sohrevardi, S. M., Chow, T. W. S., Spence, J. D., & Chiu, B. (2020). Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection. Computer Methods and Programs in Biomedicine, 184, [105276]. https://doi.org/10.1016/j.cmpb.2019.105276

Vancouver

Chen X, Lin M, Cui H, Chen Y, van Engelen A, de Bruijne M et al. Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection. Computer Methods and Programs in Biomedicine. 2020;184. 105276. https://doi.org/10.1016/j.cmpb.2019.105276

Author

Chen, Xueli ; Lin, Mingquan ; Cui, He ; Chen, Yimin ; van Engelen, Arna ; de Bruijne, Marleen ; Azarpazhooh, M Reza ; Sohrevardi, Seyed Mojtaba ; Chow, Tommy W S ; Spence, J David ; Chiu, Bernard. / Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection. In: Computer Methods and Programs in Biomedicine. 2020 ; Vol. 184.

Bibtex

@article{ba0c32f46d9d4429942217bb14893b6d,

title = "Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection",

abstract = "BACKGROUND AND OBJECTIVE: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.METHODS: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.RESULTS: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10-5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.CONCLUSION: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed.",

author = "Xueli Chen and Mingquan Lin and He Cui and Yimin Chen and {van Engelen}, Arna and {de Bruijne}, Marleen and Azarpazhooh, {M Reza} and Sohrevardi, {Seyed Mojtaba} and Chow, {Tommy W S} and Spence, {J David} and Bernard Chiu",

year = "2020",

doi = "10.1016/j.cmpb.2019.105276",

language = "English",

volume = "184",

journal = "Computer Methods and Programs in Biomedicine",

issn = "0169-2607",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection

AU - Chen, Xueli

AU - Lin, Mingquan

AU - Cui, He

AU - Chen, Yimin

AU - van Engelen, Arna

AU - de Bruijne, Marleen

AU - Azarpazhooh, M Reza

AU - Sohrevardi, Seyed Mojtaba

AU - Chow, Tommy W S

AU - Spence, J David

AU - Chiu, Bernard

PY - 2020

Y1 - 2020

N2 - BACKGROUND AND OBJECTIVE: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.METHODS: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.RESULTS: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10-5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.CONCLUSION: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed.

AB - BACKGROUND AND OBJECTIVE: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.METHODS: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.RESULTS: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10-5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.CONCLUSION: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed.

U2 - 10.1016/j.cmpb.2019.105276

DO - 10.1016/j.cmpb.2019.105276

M3 - Journal article

C2 - 31887617

VL - 184

JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

SN - 0169-2607

M1 - 105276

ER -

ID: 233538541

Faculty of Law