The structure and function of vertebrate fibroblast growth factor receptor 1

Research output: Contribution to journal › Journal article › Research › peer-review

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The structure and function of vertebrate fibroblast growth factor receptor 1. / Groth, Casper; Lardelli, Michael.

In: International Journal of Developmental Biology, Vol. 46, No. 4, 2002, p. 393-400.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Groth, C & Lardelli, M 2002, 'The structure and function of vertebrate fibroblast growth factor receptor 1', International Journal of Developmental Biology, vol. 46, no. 4, pp. 393-400.

APA

Groth, C., & Lardelli, M. (2002). The structure and function of vertebrate fibroblast growth factor receptor 1. International Journal of Developmental Biology, 46(4), 393-400.

Vancouver

Groth C, Lardelli M. The structure and function of vertebrate fibroblast growth factor receptor 1. International Journal of Developmental Biology. 2002;46(4):393-400.

Author

Groth, Casper ; Lardelli, Michael. / The structure and function of vertebrate fibroblast growth factor receptor 1. In: International Journal of Developmental Biology. 2002 ; Vol. 46, No. 4. pp. 393-400.

Bibtex

@article{79c80139eff04aa7b3ac86556c4a3148,
title = "The structure and function of vertebrate fibroblast growth factor receptor 1",
abstract = "The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.",
keywords = "Alternative Splicing, Cell Nucleus, DNA, Complementary, Gene Expression Regulation, Developmental, Humans, Ligands, Membrane Proteins, Models, Biological, Protein Binding, Protein Isoforms, Protein Structure, Tertiary, Receptor Protein-Tyrosine Kinases, Receptor, Fibroblast Growth Factor, Type 1, Receptors, Fibroblast Growth Factor, Receptors, Notch, Signal Transduction, Structure-Activity Relationship, Transcription, Genetic",
author = "Casper Groth and Michael Lardelli",
year = "2002",
language = "English",
volume = "46",
pages = "393--400",
journal = "International Journal of Developmental Biology",
issn = "0214-6282",
publisher = "Universidad del Pais Vasco Servicio Editorial",
number = "4",

}

RIS

TY - JOUR

T1 - The structure and function of vertebrate fibroblast growth factor receptor 1

AU - Groth, Casper

AU - Lardelli, Michael

PY - 2002

Y1 - 2002

N2 - The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.

AB - The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.

KW - Alternative Splicing

KW - Cell Nucleus

KW - DNA, Complementary

KW - Gene Expression Regulation, Developmental

KW - Humans

KW - Ligands

KW - Membrane Proteins

KW - Models, Biological

KW - Protein Binding

KW - Protein Isoforms

KW - Protein Structure, Tertiary

KW - Receptor Protein-Tyrosine Kinases

KW - Receptor, Fibroblast Growth Factor, Type 1

KW - Receptors, Fibroblast Growth Factor

KW - Receptors, Notch

KW - Signal Transduction

KW - Structure-Activity Relationship

KW - Transcription, Genetic

M3 - Journal article

C2 - 12141425

VL - 46

SP - 393

EP - 400

JO - International Journal of Developmental Biology

JF - International Journal of Developmental Biology

SN - 0214-6282

IS - 4

ER -

ID: 128116957