The role of sleep in the pathophysiology of nocturnal enuresis

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The role of sleep in the pathophysiology of nocturnal enuresis. / Pedersen, Malthe J; Rittig, Søren; Jennum, Poul J; Kamperis, Konstantinos.

In: Sleep Medicine Reviews, Vol. 49, 101228, 2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Pedersen, MJ, Rittig, S, Jennum, PJ & Kamperis, K 2020, 'The role of sleep in the pathophysiology of nocturnal enuresis', Sleep Medicine Reviews, vol. 49, 101228. https://doi.org/10.1016/j.smrv.2019.101228

APA

Pedersen, M. J., Rittig, S., Jennum, P. J., & Kamperis, K. (2020). The role of sleep in the pathophysiology of nocturnal enuresis. Sleep Medicine Reviews, 49, [101228]. https://doi.org/10.1016/j.smrv.2019.101228

Vancouver

Pedersen MJ, Rittig S, Jennum PJ, Kamperis K. The role of sleep in the pathophysiology of nocturnal enuresis. Sleep Medicine Reviews. 2020;49. 101228. https://doi.org/10.1016/j.smrv.2019.101228

Author

Pedersen, Malthe J ; Rittig, Søren ; Jennum, Poul J ; Kamperis, Konstantinos. / The role of sleep in the pathophysiology of nocturnal enuresis. In: Sleep Medicine Reviews. 2020 ; Vol. 49.

Bibtex

@article{b08c852ed6b34f5d9ddaca8fc49f080b,

title = "The role of sleep in the pathophysiology of nocturnal enuresis",

abstract = "Nocturnal enuresis (NE) is a common condition affecting 5-10% of all 7-year-old children. NE pathophysiology relies on three main factors, abnormal bladder function, excess urine production during sleep and the inability to awaken to the signals of a full bladder. The aim of this review is to evaluate the connection between sleep and its structure and the pathophysiology of NE. NE often occurs early at night and primarily in sleep stage 2 and {"}deep sleep{"}. Although sleep stage distribution seems similar between NE and healthy children recent studies indicate differences in sleep microstructure. Several lines of research support the common notion among parents that children with NE are difficult to awaken. Moreover, children with NE and nocturnal polyuria differ in terms of hemodynamics and possibly autonomic activation at night compared to healthy controls and the hypothesis has formed that these changes are attributable to different sleep characteristics. In support of this hypothesis, children with NE often suffer sleep disordered breathing, as well as disturbed sleep due to awakenings and arousals. Periodic limb movements (PLM) have been seen in children with refractory enuresis but the clinical significance remains unclear.",

keywords = "Arousal/physiology, Humans, Nocturnal Enuresis/physiopathology, Pediatrics, Sleep/physiology, Sleep Stages",

author = "Pedersen, {Malthe J} and S{\o}ren Rittig and Jennum, {Poul J} and Konstantinos Kamperis",

year = "2020",

doi = "10.1016/j.smrv.2019.101228",

language = "English",

volume = "49",

journal = "Sleep Medicine Reviews",

issn = "1087-0792",

publisher = "Elsevier Masson",

}

RIS

TY - JOUR

T1 - The role of sleep in the pathophysiology of nocturnal enuresis

AU - Pedersen, Malthe J

AU - Rittig, Søren

AU - Jennum, Poul J

AU - Kamperis, Konstantinos

PY - 2020

Y1 - 2020

N2 - Nocturnal enuresis (NE) is a common condition affecting 5-10% of all 7-year-old children. NE pathophysiology relies on three main factors, abnormal bladder function, excess urine production during sleep and the inability to awaken to the signals of a full bladder. The aim of this review is to evaluate the connection between sleep and its structure and the pathophysiology of NE. NE often occurs early at night and primarily in sleep stage 2 and "deep sleep". Although sleep stage distribution seems similar between NE and healthy children recent studies indicate differences in sleep microstructure. Several lines of research support the common notion among parents that children with NE are difficult to awaken. Moreover, children with NE and nocturnal polyuria differ in terms of hemodynamics and possibly autonomic activation at night compared to healthy controls and the hypothesis has formed that these changes are attributable to different sleep characteristics. In support of this hypothesis, children with NE often suffer sleep disordered breathing, as well as disturbed sleep due to awakenings and arousals. Periodic limb movements (PLM) have been seen in children with refractory enuresis but the clinical significance remains unclear.

AB - Nocturnal enuresis (NE) is a common condition affecting 5-10% of all 7-year-old children. NE pathophysiology relies on three main factors, abnormal bladder function, excess urine production during sleep and the inability to awaken to the signals of a full bladder. The aim of this review is to evaluate the connection between sleep and its structure and the pathophysiology of NE. NE often occurs early at night and primarily in sleep stage 2 and "deep sleep". Although sleep stage distribution seems similar between NE and healthy children recent studies indicate differences in sleep microstructure. Several lines of research support the common notion among parents that children with NE are difficult to awaken. Moreover, children with NE and nocturnal polyuria differ in terms of hemodynamics and possibly autonomic activation at night compared to healthy controls and the hypothesis has formed that these changes are attributable to different sleep characteristics. In support of this hypothesis, children with NE often suffer sleep disordered breathing, as well as disturbed sleep due to awakenings and arousals. Periodic limb movements (PLM) have been seen in children with refractory enuresis but the clinical significance remains unclear.

KW - Arousal/physiology

KW - Humans

KW - Nocturnal Enuresis/physiopathology

KW - Pediatrics

KW - Sleep/physiology

KW - Sleep Stages

U2 - 10.1016/j.smrv.2019.101228

DO - 10.1016/j.smrv.2019.101228

M3 - Review

C2 - 31790860

VL - 49

JO - Sleep Medicine Reviews

JF - Sleep Medicine Reviews

SN - 1087-0792

M1 - 101228

ER -

ID: 257042047

Faculty of Law