Targeting the supply lines of cancer - A possible strategy for combating the disease?

Research output: Contribution to journal › Review › Research › peer-review

Standard

Targeting the supply lines of cancer - A possible strategy for combating the disease? / Abrahamsen, Oliver; Balslev, Eva; Høgdall, Estrid.

In: Anticancer Research, Vol. 41, No. 6, 2021, p. 2737-2744.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Abrahamsen, O, Balslev, E & Høgdall, E 2021, 'Targeting the supply lines of cancer - A possible strategy for combating the disease?', Anticancer Research, vol. 41, no. 6, pp. 2737-2744. https://doi.org/10.21873/anticanres.15055

APA

Abrahamsen, O., Balslev, E., & Høgdall, E. (2021). Targeting the supply lines of cancer - A possible strategy for combating the disease? Anticancer Research, 41(6), 2737-2744. https://doi.org/10.21873/anticanres.15055

Vancouver

Abrahamsen O, Balslev E, Høgdall E. Targeting the supply lines of cancer - A possible strategy for combating the disease? Anticancer Research. 2021;41(6):2737-2744. https://doi.org/10.21873/anticanres.15055

Author

Abrahamsen, Oliver ; Balslev, Eva ; Høgdall, Estrid. / Targeting the supply lines of cancer - A possible strategy for combating the disease?. In: Anticancer Research. 2021 ; Vol. 41, No. 6. pp. 2737-2744.

Bibtex

@article{5695160b518645e0ab25f36433ae95a0,
title = "Targeting the supply lines of cancer - A possible strategy for combating the disease?",
abstract = "Cancer cells alter and up-regulate their metabolic activity in order to facilitate the increased demands of malignancy. This leads to an increased need for metabolic {"}building materials{"}, for example glucose and amino acids. The blood circulation represents the principal supply lines delivering these materials. It, therefore, becomes relevant to investigate if these supply lines - in terms of the concentrations of building materials in the blood - may exhibit a therapeutic window and could be intervened, as they deliver the most basal components required to exert malignant functioning. A key aspect in this strategy is that it targets - in theory - the thermodynamic foundation enabling the activities that, essentially, {"}make a cancer a cancer{"}. As an initial step, this review examines if the metabolic supply lines carry clinical implications; specifically, if they impact survival and the development of metastases in patients with cancer. Furthermore, it presents and discusses perspectives on potentially targeting these supply lines.",
keywords = "Amino acids, Cancer, Glucose, Metabolism, Review, Survival",
author = "Oliver Abrahamsen and Eva Balslev and Estrid H{\o}gdall",
note = "Publisher Copyright: {\textcopyright} 2021 International Institute of Anticancer Research. All rights reserved.",
year = "2021",
doi = "10.21873/anticanres.15055",
language = "English",
volume = "41",
pages = "2737--2744",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "6",

}

RIS

TY - JOUR

T1 - Targeting the supply lines of cancer - A possible strategy for combating the disease?

AU - Abrahamsen, Oliver

AU - Balslev, Eva

AU - Høgdall, Estrid

N1 - Publisher Copyright: © 2021 International Institute of Anticancer Research. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Cancer cells alter and up-regulate their metabolic activity in order to facilitate the increased demands of malignancy. This leads to an increased need for metabolic "building materials", for example glucose and amino acids. The blood circulation represents the principal supply lines delivering these materials. It, therefore, becomes relevant to investigate if these supply lines - in terms of the concentrations of building materials in the blood - may exhibit a therapeutic window and could be intervened, as they deliver the most basal components required to exert malignant functioning. A key aspect in this strategy is that it targets - in theory - the thermodynamic foundation enabling the activities that, essentially, "make a cancer a cancer". As an initial step, this review examines if the metabolic supply lines carry clinical implications; specifically, if they impact survival and the development of metastases in patients with cancer. Furthermore, it presents and discusses perspectives on potentially targeting these supply lines.

AB - Cancer cells alter and up-regulate their metabolic activity in order to facilitate the increased demands of malignancy. This leads to an increased need for metabolic "building materials", for example glucose and amino acids. The blood circulation represents the principal supply lines delivering these materials. It, therefore, becomes relevant to investigate if these supply lines - in terms of the concentrations of building materials in the blood - may exhibit a therapeutic window and could be intervened, as they deliver the most basal components required to exert malignant functioning. A key aspect in this strategy is that it targets - in theory - the thermodynamic foundation enabling the activities that, essentially, "make a cancer a cancer". As an initial step, this review examines if the metabolic supply lines carry clinical implications; specifically, if they impact survival and the development of metastases in patients with cancer. Furthermore, it presents and discusses perspectives on potentially targeting these supply lines.

KW - Amino acids

KW - Cancer

KW - Glucose

KW - Metabolism

KW - Review

KW - Survival

U2 - 10.21873/anticanres.15055

DO - 10.21873/anticanres.15055

M3 - Review

C2 - 34083264

AN - SCOPUS:85107601464

VL - 41

SP - 2737

EP - 2744

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 6

ER -

ID: 302561084