Surveillance in stage I testicular cancer
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Surveillance in stage I testicular cancer. / Daugaard, Gedske; Petersen, Peter Meidahl; Rørth, Mikael.
In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 111, No. 1, 2003, p. 76-83; discussion 83-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Surveillance in stage I testicular cancer
AU - Daugaard, Gedske
AU - Petersen, Peter Meidahl
AU - Rørth, Mikael
N1 - Keywords: Adolescent; Adult; Aged; Cohort Studies; Combined Modality Therapy; Denmark; Germinoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Second Primary; Orchiectomy; Physical Examination; Population Surveillance; Seminoma; Survival Rate; Testicular Neoplasms; Time Factors; Tumor Markers, Biological
PY - 2003
Y1 - 2003
N2 - Treatment results on 695 stage I testicular cancer patients followed with surveillance are described. Seminoma (SGCT) was present in 394 patients and nonseminoma (NSGCT) in 301 patients. Relapses were detected in 155 patients (22%), in 69 patients with SGCT (17%) and 86 with NSGCT (29%). In patients with vascular invasion, relapse was detected in 54% of patients with NSGCT and 38% of patients with SGCT. Time to relapse was median 13 months (range 1 to 84 months) for SGCT and 5 months (range 1 to 171 months) for NSGCT. Forty-nine percent of relapses in SGCT patients were seen within the first year, 87% of the relapses were diagnosed within the first two years, and 98% of the relapses were detected within 5 years. The figures for NSGCT were 80%, 89% and 95%, respectively. Forty-five patients had carcinoma in situ in the contralateral testis, 62% had this together with a seminoma in the other testis. Ten patients died during the follow-up period. None of these deaths were caused by the germ cell tumour or the treatment. The overall survival for patients with stage I disease is 98.6%, and the cause specific survival 100%.
AB - Treatment results on 695 stage I testicular cancer patients followed with surveillance are described. Seminoma (SGCT) was present in 394 patients and nonseminoma (NSGCT) in 301 patients. Relapses were detected in 155 patients (22%), in 69 patients with SGCT (17%) and 86 with NSGCT (29%). In patients with vascular invasion, relapse was detected in 54% of patients with NSGCT and 38% of patients with SGCT. Time to relapse was median 13 months (range 1 to 84 months) for SGCT and 5 months (range 1 to 171 months) for NSGCT. Forty-nine percent of relapses in SGCT patients were seen within the first year, 87% of the relapses were diagnosed within the first two years, and 98% of the relapses were detected within 5 years. The figures for NSGCT were 80%, 89% and 95%, respectively. Forty-five patients had carcinoma in situ in the contralateral testis, 62% had this together with a seminoma in the other testis. Ten patients died during the follow-up period. None of these deaths were caused by the germ cell tumour or the treatment. The overall survival for patients with stage I disease is 98.6%, and the cause specific survival 100%.
M3 - Journal article
C2 - 12752240
VL - 111
SP - 76-83; discussion 83-5
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 1
ER -
ID: 19279210