Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants. / Goldstein, K; Colding, H; Andersen, G E.

In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 96, No. 4, 1988, p. 329-32.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Goldstein, K, Colding, H & Andersen, GE 1988, 'Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants.', Acta Pathologica Microbiologica et Immunologica Scandinavica, vol. 96, no. 4, pp. 329-32.

APA

Goldstein, K., Colding, H., & Andersen, G. E. (1988). Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants. Acta Pathologica Microbiologica et Immunologica Scandinavica, 96(4), 329-32.

Vancouver

Goldstein K, Colding H, Andersen GE. Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants. Acta Pathologica Microbiologica et Immunologica Scandinavica. 1988;96(4):329-32.

Author

Goldstein, K ; Colding, H ; Andersen, G E. / Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants. In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 1988 ; Vol. 96, No. 4. pp. 329-32.

Bibtex

@article{cd055f50b55211ddb04f000ea68e967b,
title = "Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants.",
abstract = "The stability of ampicillin, piperacillin and cefotaxime, alone or in combination with either netilmicin or amikacin, was tested by microbiological methods at 29 degrees C (ampicillin, also at 22 degrees C) in an L-amino acid solution specially prepared for newborn infants. In the case of ampicillin, the mean concentration had dropped to 84% of the initial value after 24 hours. This fall is acceptable. Piperacillin and cefotaxime were stable. Admixture of netilmicin or amikacin did not affect the activity of ampicillin, piperacillin and cefotaxime. The concentrations of netilmicin and amikacin were stable for 24 hours. Combination with ampicillin, piperacillin or cefotaxime did not affect the activity of either aminoglycoside. The antibiotics investigated could therefore be used in our TPN infusion system.",
author = "K Goldstein and H Colding and Andersen, {G E}",
note = "Keywords: Amikacin; Amino Acids; Ampicillin; Anti-Bacterial Agents; Cefotaxime; Drug Interactions; Drug Stability; Humans; Infant, Newborn; Netilmicin; Parenteral Nutrition, Total; Piperacillin; Temperature; Time Factors",
year = "1988",
language = "English",
volume = "96",
pages = "329--32",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "4",

}

RIS

TY - JOUR

T1 - Stability of ampicillin, piperacillin, cefotaxime, netilmicin and amikacin in an L-amino acid solution prepared for total parenteral nutrition of newborn infants.

AU - Goldstein, K

AU - Colding, H

AU - Andersen, G E

N1 - Keywords: Amikacin; Amino Acids; Ampicillin; Anti-Bacterial Agents; Cefotaxime; Drug Interactions; Drug Stability; Humans; Infant, Newborn; Netilmicin; Parenteral Nutrition, Total; Piperacillin; Temperature; Time Factors

PY - 1988

Y1 - 1988

N2 - The stability of ampicillin, piperacillin and cefotaxime, alone or in combination with either netilmicin or amikacin, was tested by microbiological methods at 29 degrees C (ampicillin, also at 22 degrees C) in an L-amino acid solution specially prepared for newborn infants. In the case of ampicillin, the mean concentration had dropped to 84% of the initial value after 24 hours. This fall is acceptable. Piperacillin and cefotaxime were stable. Admixture of netilmicin or amikacin did not affect the activity of ampicillin, piperacillin and cefotaxime. The concentrations of netilmicin and amikacin were stable for 24 hours. Combination with ampicillin, piperacillin or cefotaxime did not affect the activity of either aminoglycoside. The antibiotics investigated could therefore be used in our TPN infusion system.

AB - The stability of ampicillin, piperacillin and cefotaxime, alone or in combination with either netilmicin or amikacin, was tested by microbiological methods at 29 degrees C (ampicillin, also at 22 degrees C) in an L-amino acid solution specially prepared for newborn infants. In the case of ampicillin, the mean concentration had dropped to 84% of the initial value after 24 hours. This fall is acceptable. Piperacillin and cefotaxime were stable. Admixture of netilmicin or amikacin did not affect the activity of ampicillin, piperacillin and cefotaxime. The concentrations of netilmicin and amikacin were stable for 24 hours. Combination with ampicillin, piperacillin or cefotaxime did not affect the activity of either aminoglycoside. The antibiotics investigated could therefore be used in our TPN infusion system.

M3 - Journal article

C2 - 3130887

VL - 96

SP - 329

EP - 332

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 4

ER -

ID: 8670140