Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.
Research output: Contribution to journal › Journal article › Research › peer-review
Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.
| Original language | English |
|---|---|
| Journal | Infection and Immunity |
| Volume | 75 |
| Issue number | 1 |
| Pages (from-to) | 504-7 |
| Number of pages | 3 |
| ISSN | 0019-9567 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
Bibliographical note
Keywords: Animals; Bacterial Proteins; DNA Transposable Elements; Female; Genes, Bacterial; Humans; Macrophages; Mice; Mice, Inbred C57BL; Mutagenesis; Mycobacterium tuberculosis
ID: 5185352