Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat. / Gillum, Trevor; Kuennen, Matthew; Gourley, Cheryl; Dokladny, Karol; Schneider, Suzanne; Moseley, Pope.

In: International Journal of Endocrinology and Metabolism, Vol. 11, No. 4, e8739, 2013.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gillum, T, Kuennen, M, Gourley, C, Dokladny, K, Schneider, S & Moseley, P 2013, 'Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat', International Journal of Endocrinology and Metabolism, vol. 11, no. 4, e8739. https://doi.org/10.5812/ijem.8739

APA

Gillum, T., Kuennen, M., Gourley, C., Dokladny, K., Schneider, S., & Moseley, P. (2013). Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat. International Journal of Endocrinology and Metabolism, 11(4), [e8739]. https://doi.org/10.5812/ijem.8739

Vancouver

Gillum T, Kuennen M, Gourley C, Dokladny K, Schneider S, Moseley P. Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat. International Journal of Endocrinology and Metabolism. 2013;11(4). e8739. https://doi.org/10.5812/ijem.8739

Author

Gillum, Trevor ; Kuennen, Matthew ; Gourley, Cheryl ; Dokladny, Karol ; Schneider, Suzanne ; Moseley, Pope. / Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat. In: International Journal of Endocrinology and Metabolism. 2013 ; Vol. 11, No. 4.

Bibtex

@article{2cf0f9320356480d85714434a86d1ba2,
title = "Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat",
abstract = "BACKGROUND: Heat shock protein 72 (Hsp72) is responsible for maintaining critical cellular function during heat stress. Hsp72 confers thermotolerance and may play a role in heat acclimation. Animal research suggests a difference between sexes in Hsp72 expression in response to exercise, however, human data is lacking.OBJECTIVES: To determine sex differences in intracellular heat shock protein 72 (Hsp72) following exercise in the heat.PATIENTS AND METHODS: Nine non-heat acclimated women with normal menstrual cycles (VO2pk 58 ± 5 mL.kgFFM(-1).min(-1)) and nine non-heat acclimated men (VO2pk 60 ± 7 ml.kgFFM(-1).min(-1)) completed 2 treadmill bouts at 60% VO2pk for 60 min in a 42°C, 20% RH environment. Women were tested in follicular (fol) and luteal (lut) phases. The duplicate trials were separated by 12 days for men and women. Blood samples were drawn pre, immediately post, 1, and 4 hrs post-exercise.RESULTS: Men and women differed in their Hsp72 response after exercise (time X sex X trial interaction; P < 0.05). Men increased Hsp72 after exercise more than women. Both men and women produced less Hsp72 during trial 2 compared to trial 1. Estrogen (r = 0.24; P > 0.05) and progesterone (r = 0.27, P > 0.05) concentrations were not correlated with Hsp72.CONCLUSION: Our findings suggest that men and women differ in their cellular stress response. Men up-regulated Hsp72 after a single bout of exercise in the heat, which persists for 12 days, suggesting an accumulation of Hsp72 which may lead to acquired cellular thermotolerance.",
author = "Trevor Gillum and Matthew Kuennen and Cheryl Gourley and Karol Dokladny and Suzanne Schneider and Pope Moseley",
year = "2013",
doi = "10.5812/ijem.8739",
language = "English",
volume = "11",
journal = "International Journal of Endocrinology and Metabolism",
issn = "1726-913X",
publisher = "Kowsar Corporation",
number = "4",

}

RIS

TY - JOUR

T1 - Sex differences in heat shock protein 72 expression in peripheral blood mononuclear cells to acute exercise in the heat

AU - Gillum, Trevor

AU - Kuennen, Matthew

AU - Gourley, Cheryl

AU - Dokladny, Karol

AU - Schneider, Suzanne

AU - Moseley, Pope

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Heat shock protein 72 (Hsp72) is responsible for maintaining critical cellular function during heat stress. Hsp72 confers thermotolerance and may play a role in heat acclimation. Animal research suggests a difference between sexes in Hsp72 expression in response to exercise, however, human data is lacking.OBJECTIVES: To determine sex differences in intracellular heat shock protein 72 (Hsp72) following exercise in the heat.PATIENTS AND METHODS: Nine non-heat acclimated women with normal menstrual cycles (VO2pk 58 ± 5 mL.kgFFM(-1).min(-1)) and nine non-heat acclimated men (VO2pk 60 ± 7 ml.kgFFM(-1).min(-1)) completed 2 treadmill bouts at 60% VO2pk for 60 min in a 42°C, 20% RH environment. Women were tested in follicular (fol) and luteal (lut) phases. The duplicate trials were separated by 12 days for men and women. Blood samples were drawn pre, immediately post, 1, and 4 hrs post-exercise.RESULTS: Men and women differed in their Hsp72 response after exercise (time X sex X trial interaction; P < 0.05). Men increased Hsp72 after exercise more than women. Both men and women produced less Hsp72 during trial 2 compared to trial 1. Estrogen (r = 0.24; P > 0.05) and progesterone (r = 0.27, P > 0.05) concentrations were not correlated with Hsp72.CONCLUSION: Our findings suggest that men and women differ in their cellular stress response. Men up-regulated Hsp72 after a single bout of exercise in the heat, which persists for 12 days, suggesting an accumulation of Hsp72 which may lead to acquired cellular thermotolerance.

AB - BACKGROUND: Heat shock protein 72 (Hsp72) is responsible for maintaining critical cellular function during heat stress. Hsp72 confers thermotolerance and may play a role in heat acclimation. Animal research suggests a difference between sexes in Hsp72 expression in response to exercise, however, human data is lacking.OBJECTIVES: To determine sex differences in intracellular heat shock protein 72 (Hsp72) following exercise in the heat.PATIENTS AND METHODS: Nine non-heat acclimated women with normal menstrual cycles (VO2pk 58 ± 5 mL.kgFFM(-1).min(-1)) and nine non-heat acclimated men (VO2pk 60 ± 7 ml.kgFFM(-1).min(-1)) completed 2 treadmill bouts at 60% VO2pk for 60 min in a 42°C, 20% RH environment. Women were tested in follicular (fol) and luteal (lut) phases. The duplicate trials were separated by 12 days for men and women. Blood samples were drawn pre, immediately post, 1, and 4 hrs post-exercise.RESULTS: Men and women differed in their Hsp72 response after exercise (time X sex X trial interaction; P < 0.05). Men increased Hsp72 after exercise more than women. Both men and women produced less Hsp72 during trial 2 compared to trial 1. Estrogen (r = 0.24; P > 0.05) and progesterone (r = 0.27, P > 0.05) concentrations were not correlated with Hsp72.CONCLUSION: Our findings suggest that men and women differ in their cellular stress response. Men up-regulated Hsp72 after a single bout of exercise in the heat, which persists for 12 days, suggesting an accumulation of Hsp72 which may lead to acquired cellular thermotolerance.

U2 - 10.5812/ijem.8739

DO - 10.5812/ijem.8739

M3 - Journal article

C2 - 24719632

VL - 11

JO - International Journal of Endocrinology and Metabolism

JF - International Journal of Endocrinology and Metabolism

SN - 1726-913X

IS - 4

M1 - e8739

ER -

ID: 202296499