Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism. / Thystrup, Christa Koll; Vangkilde, Signe; Ozenne, Brice; Stenbæk, Dea Siggaard.

In: Psychiatry Research, Vol. 291, 113029, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thystrup, CK, Vangkilde, S, Ozenne, B & Stenbæk, DS 2020, 'Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism', Psychiatry Research, vol. 291, 113029. https://doi.org/10.1016/j.psychres.2020.113029

APA

Thystrup, C. K., Vangkilde, S., Ozenne, B., & Stenbæk, D. S. (2020). Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism. Psychiatry Research, 291, [113029]. https://doi.org/10.1016/j.psychres.2020.113029

Vancouver

Thystrup CK, Vangkilde S, Ozenne B, Stenbæk DS. Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism. Psychiatry Research. 2020;291. 113029. https://doi.org/10.1016/j.psychres.2020.113029

Author

Thystrup, Christa Koll ; Vangkilde, Signe ; Ozenne, Brice ; Stenbæk, Dea Siggaard. / Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism. In: Psychiatry Research. 2020 ; Vol. 291.

Bibtex

@article{6c7adc592da8430ca54c70ce63362dfd,
title = "Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism",
abstract = "Background: The length of the serotonin transporter polymorphic region (5-HTTLPR) has been suggested to be associated with risk for developing depression, though with inconsistent evidence. Likewise, the personality trait Harm Avoidance (HA) has been linked to vulnerability for developing depression. However, no study has investigated whether there is an interaction effect between 5-HTTLPR and trait HA on depressive symptoms in healthy individuals. Methods: A total of 319 healthy individuals were included in this cross-sectional study. All participants were genotyped for the 5-HTTLPR polymorphism and completed self-reported measures of personality trait HA with the Temperament and Character Inventory (TCI), and of depression with the Major Depression Inventory (MDI). Linear regression analyses were used to test interaction effects between 5-HTTLPR and HA on MDI. Post hoc analyses were further performed to investigate main effects of HA and possible interaction effects between 5-HTTLPR and HA sub-scales on MDI. Results: No significant interaction effect between 5-HTTLPR and HA on MDI was found. A significant main effect of trait HA on MDI was found, indicating that personality trait HA is a viable vulnerability factor for even sub-clinical depressive symptoms. Conclusion: This study finds a strong significant relationship between HA and MDI. Moreover, the present study supports the line of research indicating that candidate gene-by-interactions does not increase vulnerability for developing depression even at a sub-clinical level.",
keywords = "5-HTTLPR, depression, Harm Avoidance, Serotonin transporter polymorphism, vulnerability",
author = "Thystrup, {Christa Koll} and Signe Vangkilde and Brice Ozenne and Stenb{\ae}k, {Dea Siggaard}",
year = "2020",
doi = "10.1016/j.psychres.2020.113029",
language = "English",
volume = "291",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism

AU - Thystrup, Christa Koll

AU - Vangkilde, Signe

AU - Ozenne, Brice

AU - Stenbæk, Dea Siggaard

PY - 2020

Y1 - 2020

N2 - Background: The length of the serotonin transporter polymorphic region (5-HTTLPR) has been suggested to be associated with risk for developing depression, though with inconsistent evidence. Likewise, the personality trait Harm Avoidance (HA) has been linked to vulnerability for developing depression. However, no study has investigated whether there is an interaction effect between 5-HTTLPR and trait HA on depressive symptoms in healthy individuals. Methods: A total of 319 healthy individuals were included in this cross-sectional study. All participants were genotyped for the 5-HTTLPR polymorphism and completed self-reported measures of personality trait HA with the Temperament and Character Inventory (TCI), and of depression with the Major Depression Inventory (MDI). Linear regression analyses were used to test interaction effects between 5-HTTLPR and HA on MDI. Post hoc analyses were further performed to investigate main effects of HA and possible interaction effects between 5-HTTLPR and HA sub-scales on MDI. Results: No significant interaction effect between 5-HTTLPR and HA on MDI was found. A significant main effect of trait HA on MDI was found, indicating that personality trait HA is a viable vulnerability factor for even sub-clinical depressive symptoms. Conclusion: This study finds a strong significant relationship between HA and MDI. Moreover, the present study supports the line of research indicating that candidate gene-by-interactions does not increase vulnerability for developing depression even at a sub-clinical level.

AB - Background: The length of the serotonin transporter polymorphic region (5-HTTLPR) has been suggested to be associated with risk for developing depression, though with inconsistent evidence. Likewise, the personality trait Harm Avoidance (HA) has been linked to vulnerability for developing depression. However, no study has investigated whether there is an interaction effect between 5-HTTLPR and trait HA on depressive symptoms in healthy individuals. Methods: A total of 319 healthy individuals were included in this cross-sectional study. All participants were genotyped for the 5-HTTLPR polymorphism and completed self-reported measures of personality trait HA with the Temperament and Character Inventory (TCI), and of depression with the Major Depression Inventory (MDI). Linear regression analyses were used to test interaction effects between 5-HTTLPR and HA on MDI. Post hoc analyses were further performed to investigate main effects of HA and possible interaction effects between 5-HTTLPR and HA sub-scales on MDI. Results: No significant interaction effect between 5-HTTLPR and HA on MDI was found. A significant main effect of trait HA on MDI was found, indicating that personality trait HA is a viable vulnerability factor for even sub-clinical depressive symptoms. Conclusion: This study finds a strong significant relationship between HA and MDI. Moreover, the present study supports the line of research indicating that candidate gene-by-interactions does not increase vulnerability for developing depression even at a sub-clinical level.

KW - 5-HTTLPR

KW - depression

KW - Harm Avoidance

KW - Serotonin transporter polymorphism

KW - vulnerability

U2 - 10.1016/j.psychres.2020.113029

DO - 10.1016/j.psychres.2020.113029

M3 - Journal article

C2 - 32619821

AN - SCOPUS:85087215715

VL - 291

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 113029

ER -

ID: 248847873