Serological identification of neoantigens on mouse fibroblasts which have undergone "spontaneous" malignant alteration in vitro.
Research output: Contribution to journal › Journal article › Research › peer-review
ST-L1 is a cell line established from lung explants from a normal ST/a mouse. The ST-L1 cells have undergone spontaneous malignant alteration in vitro. The cells were rejected after inoculation into syngeneic immunocompetent hosts, and a syngeneic humoral immuneresponse against the ST-L1 cells has been detected. The specificity of this humoral response was investigated. The syngeneic response to ST-L1 was characterized by indirect immunofluorescence tests and by immunoprecipitation of radiolabelled cells and of a C-type virus produced by the cell lines. The specific anti-ST-L1 reactivities were found to be directed against the envelope glycoprotein of an endogenous C-type virus expressed by the antigenic cell line.
Original language | English |
---|---|
Journal | International Journal of Cancer |
Volume | 23 |
Issue number | 2 |
Pages (from-to) | 209-16 |
Number of pages | 7 |
ISSN | 0020-7136 |
Publication status | Published - 1979 |
Bibliographical note
Keywords: Animals; Cell Line; Cell Transformation, Neoplastic; Cross Reactions; Epitopes; Fibroblasts; Fluorescent Antibody Technique; Immune Sera; Mice; Precipitation; Radioimmunoassay; Retroviridae; Viral Proteins
ID: 2890715