Seizure deterioration in women treated with oxcarbazepine during pregnancy
Research output: Contribution to journal › Journal article › Research › peer-review
Thirteen pregnancies in ten women on oxcarbazepine (OXC) monotherapy and one pregnancy in a woman on OXC and topiramate therapy were retrospectively analyzed. A significant decrease of ratio plasma concentration of 10-monohydroxy derivate (MHD) of oxcarbazepine to dosage was found by 26.2% during first trimester, by 36.5% during second trimester and by 38.2% during third trimester when compared to pre-pregnant levels. Eight patients experienced seizure deterioration during the pregnancy, five of which had been seizure-free before the pregnancy. In seven pregnancies (50%) the seizure frequency was at least doubled during pregnancy compared to a pre-pregnancy baseline. There was a trend toward a correlation between seizure deterioration and decrease in plasma concentration of MHD.
Original language | English |
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Journal | Epilepsy Research |
Volume | 84 |
Issue number | 2-3 |
Pages (from-to) | 245-9 |
Number of pages | 4 |
ISSN | 0920-1211 |
DOIs | |
Publication status | Published - 2009 |
Bibliographical note
Keywords: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimesters; Retrospective Studies; Seizures
ID: 21406310