Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Research output: Contribution to journalReviewResearchpeer-review

Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

Original languageEnglish
JournalFertility and Sterility
Volume109
Issue number5
Pages (from-to)749-755
Number of pages7
ISSN0015-0282
DOIs
Publication statusPublished - 2018

    Research areas

  • ART, GnRH agonist, luteal phase support, ovarian stimulation, Progesterone

ID: 218518338