Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia
Research output: Contribution to journal › Journal article › Research › peer-review
Telomeres generally shorten with age. An accelerated shortening of the telomeres has been linked to several age-related disorders. We hypothesized that the relative length of telomeres could discriminate between patients with late-onset Alzheimer's disease (AD) and vascular dementia (VaD). A quantitative real-time PCR method was used to calculate the relative telomere length in 76 age-matched and sex-matched, newly diagnosed late-onset AD or VaD patients recruited from our Memory Unit. No significant difference was found in the relative telomere length between AD and VaD cases neither in men (P=0.315) nor women (P=0.12). Thus, we could not confirm that the length of telomeres would predict which form of dementia, late-onset AD or VaD that develops.
Original language | English |
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Journal | NeuroReport |
Volume | 19 |
Issue number | 12 |
Pages (from-to) | 1199-202 |
Number of pages | 4 |
ISSN | 0959-4965 |
DOIs | |
Publication status | Published - 6 Aug 2008 |
Externally published | Yes |
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Base Sequence, Child, Child, Preschool, Dementia, Vascular, Female, Humans, Male, Polymerase Chain Reaction, Telomere
Research areas
ID: 46848203