Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14
Research output: Contribution to journal › Journal article › Research › peer-review
Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.
| Original language | English |
|---|---|
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 45 |
| Issue number | 5 |
| Pages (from-to) | 1591-4 |
| Number of pages | 4 |
| ISSN | 0066-4804 |
| DOIs | |
| Publication status | Published - 1 May 2001 |
ID: 34101753