Phase I study of the cisplatin analogue 1,1-diamminomethylcyclohexane sulfatoplatinum (TNO-6) (NSC 311056).
Research output: Contribution to journal › Journal article › Research › peer-review
The cisplatin derivative TNO-6 was evaluated for clinical toxicity in a phase I trial. TNO-6 was given daily for 5 days every 3 weeks as a 30-min IV infusion without hydration. In all, 39 patients with advanced cancer were treated at doses of 2.5-9.0 mg/m2. No dose-limiting nephrotoxicity occurred, but evidence of mild, reversible tubular damage was found. Dose-limiting toxicity was hematologic with both thrombopenia and leukocytopenia, which with high dose levels reached WHO grade 4. Hematologic toxicity was most pronounced for pretreated patients. No antitumor activity was seen. The recommended dose for phase II trials will be 9.0 mg/m2 for previously untreated and 8.0 mg/m2 for pretreated patients.
Original language | English |
---|---|
Journal | Cancer Chemotherapy and Pharmacology |
Volume | 15 |
Issue number | 2 |
Pages (from-to) | 97-100 |
Number of pages | 3 |
ISSN | 0344-5704 |
Publication status | Published - 1985 |
Bibliographical note
Keywords: Adult; Aged; Drug Evaluation; Female; Humans; Iodohippuric Acid; Kidney Tubules; Leukopenia; Male; Middle Aged; Nausea; Neoplasms; Organoplatinum Compounds; Pentetic Acid; Proteinuria; Technetium; Technetium Tc 99m Pentetate; Thrombocytopenia
ID: 8746841