Peptide nucleic acids and their potential applications in biotechnology
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Peptide nucleic acids and their potential applications in biotechnology. / Buchardt, O; Berg, Rolf H.; Egholm, Michael; Nielsen, Peter E.
In: Trends in Biotechnology, Vol. 11, No. 9, 09.1993, p. 384-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Peptide nucleic acids and their potential applications in biotechnology
AU - Buchardt, O
AU - Berg, Rolf H.
AU - Egholm, Michael
AU - Nielsen, Peter E.
PY - 1993/9
Y1 - 1993/9
N2 - Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.
AB - Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.
KW - Biotechnology
KW - DNA/chemistry
KW - DNA, Antisense/chemical synthesis
KW - Drug Design
KW - Molecular Conformation
KW - Molecular Structure
KW - Nucleic Acid Conformation
KW - Nucleic Acids/chemical synthesis
KW - Peptides/chemical synthesis
KW - RNA/chemistry
KW - RNA, Antisense/chemical synthesis
KW - Structure-Activity Relationship
U2 - 10.1016/0167-7799(93)90097-S
DO - 10.1016/0167-7799(93)90097-S
M3 - Journal article
C2 - 7691090
VL - 11
SP - 384
EP - 386
JO - Trends in Biotechnology
JF - Trends in Biotechnology
SN - 0167-7799
IS - 9
ER -
ID: 203630719