Parental alcohol use disorder with and without other mental disorders and offspring alcohol use disorder
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Parental alcohol use disorder with and without other mental disorders and offspring alcohol use disorder. / Holst, C.; Tolstrup, J. S.; Sørensen, H. J.; Pisinger, V. S.C.; Becker, U.
In: Acta Psychiatrica Scandinavica, Vol. 139, No. 6, 2019, p. 508-517.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Parental alcohol use disorder with and without other mental disorders and offspring alcohol use disorder
AU - Holst, C.
AU - Tolstrup, J. S.
AU - Sørensen, H. J.
AU - Pisinger, V. S.C.
AU - Becker, U.
PY - 2019
Y1 - 2019
N2 - Objective: To examine the association between parental alcohol use disorder (AUD) with and without other mental disorders and offspring AUD. Methods: Using data from Danish nationwide registers, we identified 15 477 offspring with parental AUD and 154 392 reference individuals from the general population. Parental AUD was defined as registration for AUD treatment. Parental mental disorders were identified in medical registers and comprised psychotic, mood, anxiety, personality, drug use, and other non-alcohol-related mental disorders. AUD in offspring was identified from medical, pharmacy, treatment and cause of death registers. Hazard ratios (HRs) of AUD were estimated using Cox regression models. Results: AUD in one or both parents was associated with higher risks of AUD in offspring compared with reference individuals. Paternal AUD plus other mental disorder (HR = 2.27, 95% confidence interval (CI): 2.10–2.46) and paternal AUD alone (HR = 2.21, 95% CI: 2.07–2.36) were associated with higher offspring AUD risk. Similarly, maternal AUD plus other mental disorder (HR = 3.02, 95% CI: 2.66–3.43) and maternal AUD alone (HR = 2.57, 95% CI: 2.20–3.01) were associated with higher offspring AUD risk. Conclusions: Offspring with parental AUD are at increased risk of AUD irrespective of exposure to other parental mental disorders.
AB - Objective: To examine the association between parental alcohol use disorder (AUD) with and without other mental disorders and offspring AUD. Methods: Using data from Danish nationwide registers, we identified 15 477 offspring with parental AUD and 154 392 reference individuals from the general population. Parental AUD was defined as registration for AUD treatment. Parental mental disorders were identified in medical registers and comprised psychotic, mood, anxiety, personality, drug use, and other non-alcohol-related mental disorders. AUD in offspring was identified from medical, pharmacy, treatment and cause of death registers. Hazard ratios (HRs) of AUD were estimated using Cox regression models. Results: AUD in one or both parents was associated with higher risks of AUD in offspring compared with reference individuals. Paternal AUD plus other mental disorder (HR = 2.27, 95% confidence interval (CI): 2.10–2.46) and paternal AUD alone (HR = 2.21, 95% CI: 2.07–2.36) were associated with higher offspring AUD risk. Similarly, maternal AUD plus other mental disorder (HR = 3.02, 95% CI: 2.66–3.43) and maternal AUD alone (HR = 2.57, 95% CI: 2.20–3.01) were associated with higher offspring AUD risk. Conclusions: Offspring with parental AUD are at increased risk of AUD irrespective of exposure to other parental mental disorders.
KW - alcohol drinking
KW - alcohol use disorder
KW - alcoholism
KW - cohort studies
KW - epidemiology
KW - mental disorders
U2 - 10.1111/acps.13002
DO - 10.1111/acps.13002
M3 - Journal article
C2 - 30689217
AN - SCOPUS:85061921357
VL - 139
SP - 508
EP - 517
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 6
ER -
ID: 214337614