Membrane potential plays a dual role for chloride transport across toad skin
Research output: Contribution to journal › Journal article › Research › peer-review
The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.
Original language | English |
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Journal | BBA General Subjects |
Volume | 728 |
Issue number | 3 |
Pages (from-to) | 455-9 |
Number of pages | 5 |
ISSN | 0304-4165 |
Publication status | Published - 9 Mar 1983 |
- Animals, Biological Transport, Active, Bufo bufo, Cell Membrane, Chlorides, Computers, Epithelium, Kinetics, Membrane Potentials, Skin Physiological Phenomena
Research areas
ID: 103932136