Kinetics and dose calculations of ampicillin and gentamicin given as continuous intravenous infusion during parenteral nutrition in 88 newborn infants.
Research output: Contribution to journal › Journal article › Research › peer-review
Ampicillin and gentamicin were administered continuously intravenously to 88 newborn infants using individually calculated dosages. For infants with a mean value of plasma clearance of the antibiotics, it was calculated that the serum ampicillin and gentamicin concentrations would be between 35-55 and 3-5 micrograms/ml, respectively, using the dosages for intermittent treatment. These dosages are therefore recommended as fixed dosages for continuous intravenous infusion initiated by a bolus dosage. Serum gentamicin concentration should be assayed about three half-lives after start of infusion and the dosage adjusted for values outside 3-5 micrograms/ml.
Original language | English |
---|---|
Journal | Developmental Pharmacology and Therapeutics |
Volume | 6 |
Issue number | 6 |
Pages (from-to) | 365-73 |
Number of pages | 8 |
ISSN | 0379-8305 |
Publication status | Published - 1983 |
Bibliographical note
Keywords: Ampicillin; Female; Gentamicins; Half-Life; Humans; Infant, Newborn; Infusions, Parenteral; Kinetics; Male; Parenteral Nutrition
ID: 8670182