Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells.

Research output: Contribution to journal › Journal article › Research › peer-review

  • Flemming Fryd Johansen
  • M B Jørgensen
  • N H Diemer
Hippocampal CA-1 pyramidal cell damage was produced by 20 min of cerebral ischemia. Colchicine destruction of the dentate gyrus granule cells 11 days before ischemia prevented the CA-1 cell loss. It is suggested that the protective effect of degranulation on ischemic CA-1 pyramidal cell damage is due to reduction of glutamate release in CA-1 during and after ischemia.
Original languageEnglish
JournalBrain Research
Volume377
Issue number2
Pages (from-to)344-7
Number of pages3
ISSN0006-8993
Publication statusPublished - 1986
Externally publishedYes

Bibliographical note

Keywords: Animals; Colchicine; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Transmission

ID: 5259527