Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow in patients with benign intracranial hypertension (pseudotumor cerebri)
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Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow in patients with benign intracranial hypertension (pseudotumor cerebri). / Gjerris, F; Soelberg Sørensen, P; Vorstrup, S; Paulson, O B.
In: Annals of Neurology, Vol. 17, No. 2, 02.1985, p. 158-62.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow in patients with benign intracranial hypertension (pseudotumor cerebri)
AU - Gjerris, F
AU - Soelberg Sørensen, P
AU - Vorstrup, S
AU - Paulson, O B
PY - 1985/2
Y1 - 1985/2
N2 - Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow were investigated in 14 patients with benign intracranial hypertension (pseudotumor cerebri). Intracranial pressure was increased in 9 patients (20 to 30 mm Hg), borderline in 4 patients (15 to 18 mm Hg), and normal in 1 patient (8 mm Hg). Six patients had plateau waves, and all had B waves in more than 50% of the monitored time. Conductance to cerebrospinal fluid outflow, measured by a lumbo-lumbar perfusion method, was significantly reduced: 0.042 ml X mm Hg-1 X min-1 (+/- 0.004 [SEM]; normal, more than 0.080 ml X mm Hg-1 X min-1). Cerebral blood flow was measured by xenon 133 inhalation and single photon emission computer tomography. Mean hemispheric flow was normal in all cases, averaging 59 +/- 9 ml X 100 gm-1 X min-1. Only 2 patients showed focal low-flow areas. Thus, a disturbance of cerebrospinal fluid circulation seems to be of pathogenetic significance in benign intracranial hypertension.
AB - Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow were investigated in 14 patients with benign intracranial hypertension (pseudotumor cerebri). Intracranial pressure was increased in 9 patients (20 to 30 mm Hg), borderline in 4 patients (15 to 18 mm Hg), and normal in 1 patient (8 mm Hg). Six patients had plateau waves, and all had B waves in more than 50% of the monitored time. Conductance to cerebrospinal fluid outflow, measured by a lumbo-lumbar perfusion method, was significantly reduced: 0.042 ml X mm Hg-1 X min-1 (+/- 0.004 [SEM]; normal, more than 0.080 ml X mm Hg-1 X min-1). Cerebral blood flow was measured by xenon 133 inhalation and single photon emission computer tomography. Mean hemispheric flow was normal in all cases, averaging 59 +/- 9 ml X 100 gm-1 X min-1. Only 2 patients showed focal low-flow areas. Thus, a disturbance of cerebrospinal fluid circulation seems to be of pathogenetic significance in benign intracranial hypertension.
KW - Adolescent
KW - Adult
KW - Cerebrospinal Fluid/physiology
KW - Cerebrovascular Circulation
KW - Child
KW - Female
KW - Humans
KW - Intracranial Pressure
KW - Male
KW - Middle Aged
KW - Pseudotumor Cerebri/diagnostic imaging
KW - Radiography
KW - Tomography, Emission-Computed
KW - Xenon Radioisotopes
U2 - 10.1002/ana.410170209
DO - 10.1002/ana.410170209
M3 - Journal article
C2 - 3872097
VL - 17
SP - 158
EP - 162
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 2
ER -
ID: 275605596