Infective endocarditis: long-term reversibility of kidney function impairment. A 1-y post-discharge follow-up study
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Infective endocarditis: long-term reversibility of kidney function impairment. A 1-y post-discharge follow-up study. / Buchholtz, Kristine; Larsen, Carsten T; Hassager, Christian; Bruun, Niels E.
In: Scandinavian Journal of Infectious Diseases, Vol. 42, No. 6-7, 01.07.2010, p. 484-90.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Infective endocarditis: long-term reversibility of kidney function impairment. A 1-y post-discharge follow-up study
AU - Buchholtz, Kristine
AU - Larsen, Carsten T
AU - Hassager, Christian
AU - Bruun, Niels E
PY - 2010/7/1
Y1 - 2010/7/1
N2 - The aim of this study was to quantify the long-term reversibility of kidney function decrease occurring during hospitalization and treatment for infective endocarditis (IE). A prospective observational cohort study was performed at a tertiary university hospital in Copenhagen from October 2002 through May 2008; 223 consecutive IE patients were included. Forty patients died in hospital and 38 within 1 y of discharge. Of the 145 patients called in for the 1-y follow-up, 111 accepted. Kidney function was assessed by estimated endogenous creatinine clearance (EECC). Statistical correlation between EECC at admission, discharge and follow-up, as well as correlations between gentamicin and EECC changes, were analyzed. In the 111 follow-up patients, the bacteriological aetiologies were: Streptococcus species (47.7%), Enterococcus (16.2%) and Staphylococcus aureus (11.7%). The mean EECC decrease from admission to discharge was 8.4% (95% confidence interval 1.6-15.2; p <0.001). However this kidney function impairment was reversed at the 1-y follow-up. When divided into subgroups, a full kidney function restitution was seen in only 35.1% of patients with an EECC decrease of >22%. In conclusion, kidney function impairment occurring during hospitalization for IE is potentially reversible within the first y post-discharge.
AB - The aim of this study was to quantify the long-term reversibility of kidney function decrease occurring during hospitalization and treatment for infective endocarditis (IE). A prospective observational cohort study was performed at a tertiary university hospital in Copenhagen from October 2002 through May 2008; 223 consecutive IE patients were included. Forty patients died in hospital and 38 within 1 y of discharge. Of the 145 patients called in for the 1-y follow-up, 111 accepted. Kidney function was assessed by estimated endogenous creatinine clearance (EECC). Statistical correlation between EECC at admission, discharge and follow-up, as well as correlations between gentamicin and EECC changes, were analyzed. In the 111 follow-up patients, the bacteriological aetiologies were: Streptococcus species (47.7%), Enterococcus (16.2%) and Staphylococcus aureus (11.7%). The mean EECC decrease from admission to discharge was 8.4% (95% confidence interval 1.6-15.2; p <0.001). However this kidney function impairment was reversed at the 1-y follow-up. When divided into subgroups, a full kidney function restitution was seen in only 35.1% of patients with an EECC decrease of >22%. In conclusion, kidney function impairment occurring during hospitalization for IE is potentially reversible within the first y post-discharge.
U2 - http://dx.doi.org/10.3109/00365541003694764
DO - http://dx.doi.org/10.3109/00365541003694764
M3 - Journal article
VL - 42
SP - 484
EP - 490
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 6-7
ER -
ID: 34094495