Importance of Attenuation Correction (AC) for Small Animal PET Imaging

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Importance of Attenuation Correction (AC) for Small Animal PET Imaging. / El Ali, Henrik H.; Bodholdt, Rasmus Poul; Jørgensen, Jesper Tranekjær; Myschetzky, Rebecca Sue Main; Kjær, Andreas.

In: Diagnostics, Vol. 2, No. 4, 09.10.2012, p. 42-51.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

El Ali, HH, Bodholdt, RP, Jørgensen, JT, Myschetzky, RSM & Kjær, A 2012, 'Importance of Attenuation Correction (AC) for Small Animal PET Imaging', Diagnostics, vol. 2, no. 4, pp. 42-51. https://doi.org/10.3390/diagnostics2040042

APA

El Ali, H. H., Bodholdt, R. P., Jørgensen, J. T., Myschetzky, R. S. M., & Kjær, A. (2012). Importance of Attenuation Correction (AC) for Small Animal PET Imaging. Diagnostics, 2(4), 42-51. https://doi.org/10.3390/diagnostics2040042

Vancouver

El Ali HH, Bodholdt RP, Jørgensen JT, Myschetzky RSM, Kjær A. Importance of Attenuation Correction (AC) for Small Animal PET Imaging. Diagnostics. 2012 Oct 9;2(4):42-51. https://doi.org/10.3390/diagnostics2040042

Author

El Ali, Henrik H. ; Bodholdt, Rasmus Poul ; Jørgensen, Jesper Tranekjær ; Myschetzky, Rebecca Sue Main ; Kjær, Andreas. / Importance of Attenuation Correction (AC) for Small Animal PET Imaging. In: Diagnostics. 2012 ; Vol. 2, No. 4. pp. 42-51.

Bibtex

@article{bec18e25c74744ea86e7e98f115849ba,
title = "Importance of Attenuation Correction (AC) for Small Animal PET Imaging",
abstract = "The purpose of this study was to investigate whether a correction for annihilation photon attenuation in small objects such as mice is necessary. The attenuation recovery for specific organs and subcutaneous tumors was investigated. A comparison between different attenuation correction methods was performed. Methods: Ten NMRI nude mice with subcutaneous implantation of human breast cancer cells (MCF-7) were scanned consecutively in small animal PET and CT scanners (MicroPETTM Focus 120 and ImTek’s MicroCATTM II). CT-based AC, PET-based AC and uniform AC methods were compared. Results: The activity concentration in the same organ with and without AC revealed an overall attenuation recovery of 9–21{\%} for MAP reconstructed images, i.e., SUV without AC could underestimate the true activity at this level. For subcutaneous tumors, the attenuation was 13 ± 4{\%} (9–17{\%}), for kidneys 20 ± 1{\%} (19–21{\%}), and for bladder 18 ± 3{\%} (15–21{\%}). The FBP reconstructed images showed almost the same attenuation levels as the MAP reconstructed images for all organs. Conclusions: The annihilation photons are suffering attenuation even in small subjects. Both PET-based and CT-based are adequate as AC methods. The amplitude of the AC recovery could be overestimated using the uniform map. Therefore, application of a global attenuation factor on PET data might not be accurate for attenuation correction.",
keywords = "Faculty of Health and Medical Sciences, attenuation correction , small animal, PET imaging, MicroPET, molecular imaging",
author = "{El Ali}, {Henrik H.} and Bodholdt, {Rasmus Poul} and J{\o}rgensen, {Jesper Tranekj{\ae}r} and Myschetzky, {Rebecca Sue Main} and Andreas Kj{\ae}r",
year = "2012",
month = "10",
day = "9",
doi = "10.3390/diagnostics2040042",
language = "English",
volume = "2",
pages = "42--51",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Importance of Attenuation Correction (AC) for Small Animal PET Imaging

AU - El Ali, Henrik H.

AU - Bodholdt, Rasmus Poul

AU - Jørgensen, Jesper Tranekjær

AU - Myschetzky, Rebecca Sue Main

AU - Kjær, Andreas

PY - 2012/10/9

Y1 - 2012/10/9

N2 - The purpose of this study was to investigate whether a correction for annihilation photon attenuation in small objects such as mice is necessary. The attenuation recovery for specific organs and subcutaneous tumors was investigated. A comparison between different attenuation correction methods was performed. Methods: Ten NMRI nude mice with subcutaneous implantation of human breast cancer cells (MCF-7) were scanned consecutively in small animal PET and CT scanners (MicroPETTM Focus 120 and ImTek’s MicroCATTM II). CT-based AC, PET-based AC and uniform AC methods were compared. Results: The activity concentration in the same organ with and without AC revealed an overall attenuation recovery of 9–21% for MAP reconstructed images, i.e., SUV without AC could underestimate the true activity at this level. For subcutaneous tumors, the attenuation was 13 ± 4% (9–17%), for kidneys 20 ± 1% (19–21%), and for bladder 18 ± 3% (15–21%). The FBP reconstructed images showed almost the same attenuation levels as the MAP reconstructed images for all organs. Conclusions: The annihilation photons are suffering attenuation even in small subjects. Both PET-based and CT-based are adequate as AC methods. The amplitude of the AC recovery could be overestimated using the uniform map. Therefore, application of a global attenuation factor on PET data might not be accurate for attenuation correction.

AB - The purpose of this study was to investigate whether a correction for annihilation photon attenuation in small objects such as mice is necessary. The attenuation recovery for specific organs and subcutaneous tumors was investigated. A comparison between different attenuation correction methods was performed. Methods: Ten NMRI nude mice with subcutaneous implantation of human breast cancer cells (MCF-7) were scanned consecutively in small animal PET and CT scanners (MicroPETTM Focus 120 and ImTek’s MicroCATTM II). CT-based AC, PET-based AC and uniform AC methods were compared. Results: The activity concentration in the same organ with and without AC revealed an overall attenuation recovery of 9–21% for MAP reconstructed images, i.e., SUV without AC could underestimate the true activity at this level. For subcutaneous tumors, the attenuation was 13 ± 4% (9–17%), for kidneys 20 ± 1% (19–21%), and for bladder 18 ± 3% (15–21%). The FBP reconstructed images showed almost the same attenuation levels as the MAP reconstructed images for all organs. Conclusions: The annihilation photons are suffering attenuation even in small subjects. Both PET-based and CT-based are adequate as AC methods. The amplitude of the AC recovery could be overestimated using the uniform map. Therefore, application of a global attenuation factor on PET data might not be accurate for attenuation correction.

KW - Faculty of Health and Medical Sciences

KW - attenuation correction

KW - small animal

KW - PET imaging

KW - MicroPET

KW - molecular imaging

U2 - 10.3390/diagnostics2040042

DO - 10.3390/diagnostics2040042

M3 - Journal article

C2 - 26859397

VL - 2

SP - 42

EP - 51

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 4

ER -

ID: 47935206