Humoral and cell-mediated immune responses in DNA immunized mink challenged with wild-type canine distemper virus

Research output: Contribution to journalJournal articleResearchpeer-review

The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of CDV creates a constant viral reservoir among wildlife animals. Our results demonstrated early humoral and cell-mediated immune responses (IFN-gamma) in DNA vaccinated mink compared to mock-vaccinated mink after challenge with a Danish wild-type CDV. The DNA vaccine-induced immunity protected the natural host against disease development.
Original languageEnglish
JournalVaccine
Volume27
Issue number35
Pages (from-to)4791-4797
Number of pages7
ISSN0264-410X
DOIs
Publication statusPublished - 2009

ID: 13413254