Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition.

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Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition. / Holte, Kathrine; Kehlet, H.

In: Clinical Nutrition, Vol. 21, No. 3, 2002, p. 199-206.

Research output: Contribution to journal › Review › Research

Harvard

Holte, K & Kehlet, H 2002, 'Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition.', Clinical Nutrition, vol. 21, no. 3, pp. 199-206. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12127927&query_hl=30>

APA

Holte, K., & Kehlet, H. (2002). Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition. Clinical Nutrition, 21(3), 199-206. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12127927&query_hl=30

Vancouver

Holte K, Kehlet H. Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition. Clinical Nutrition. 2002;21(3):199-206.

Author

Holte, Kathrine ; Kehlet, H. / Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition. In: Clinical Nutrition. 2002 ; Vol. 21, No. 3. pp. 199-206.

Bibtex

@article{33fc173dad4e47878c7e47376e1e2c65,
title = "Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition.",
abstract = "BACKGROUND: Surgical injury leads to an endocrine-metabolic and inflammatory response with protein catabolism, increased cardiovascular demands, impaired pulmonary function and paralytic ileus, the most important release mechanisms being afferent neural stimuli and inflammatory mediators. RESULTS: Epidural local anaesthetic blockade of afferent stimuli reduces endocrine metabolic responses, and improve postoperative catabolism. Furthermore, dynamic pain relief is achieved with improved pulmonary function and a pronounced reduction of postoperative ileus, thereby providing optimal conditions for improved mobilization and oral nutrition, and preservation of body composition and muscle function. Studies integrating continuous epidural local anaesthetics with enforced early nutrition and mobilization uniformly suggest an improved recovery, decreased hospital stay and convalescence. CONCLUSIONS: Epidural local anaesthetics should be included in a multi-modal rehabilitation programme after major surgical procedures in order to facilitate oral nutrition, improve recovery and reduce morbidity.",
author = "Kathrine Holte and H Kehlet",
year = "2002",
language = "English",
volume = "21",
pages = "199--206",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition.

AU - Holte, Kathrine

AU - Kehlet, H

PY - 2002

Y1 - 2002

N2 - BACKGROUND: Surgical injury leads to an endocrine-metabolic and inflammatory response with protein catabolism, increased cardiovascular demands, impaired pulmonary function and paralytic ileus, the most important release mechanisms being afferent neural stimuli and inflammatory mediators. RESULTS: Epidural local anaesthetic blockade of afferent stimuli reduces endocrine metabolic responses, and improve postoperative catabolism. Furthermore, dynamic pain relief is achieved with improved pulmonary function and a pronounced reduction of postoperative ileus, thereby providing optimal conditions for improved mobilization and oral nutrition, and preservation of body composition and muscle function. Studies integrating continuous epidural local anaesthetics with enforced early nutrition and mobilization uniformly suggest an improved recovery, decreased hospital stay and convalescence. CONCLUSIONS: Epidural local anaesthetics should be included in a multi-modal rehabilitation programme after major surgical procedures in order to facilitate oral nutrition, improve recovery and reduce morbidity.

AB - BACKGROUND: Surgical injury leads to an endocrine-metabolic and inflammatory response with protein catabolism, increased cardiovascular demands, impaired pulmonary function and paralytic ileus, the most important release mechanisms being afferent neural stimuli and inflammatory mediators. RESULTS: Epidural local anaesthetic blockade of afferent stimuli reduces endocrine metabolic responses, and improve postoperative catabolism. Furthermore, dynamic pain relief is achieved with improved pulmonary function and a pronounced reduction of postoperative ileus, thereby providing optimal conditions for improved mobilization and oral nutrition, and preservation of body composition and muscle function. Studies integrating continuous epidural local anaesthetics with enforced early nutrition and mobilization uniformly suggest an improved recovery, decreased hospital stay and convalescence. CONCLUSIONS: Epidural local anaesthetics should be included in a multi-modal rehabilitation programme after major surgical procedures in order to facilitate oral nutrition, improve recovery and reduce morbidity.

M3 - Review

VL - 21

SP - 199

EP - 206

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 3

ER -

ID: 34175026