Effect of cisplatin on renal haemodynamics and tubular function in the dog kidney.
Research output: Contribution to journal › Journal article › Research › peer-review
Administration of cisplatin (5 mg/kg) to dogs results in polyuric renal failure due initially to a proximal tubular functional impairment. 48-72 h after the cisplatin administration the depressed renal function can be attributed to impairment of proximal as well as distal tubular reabsorptive capacities associated with increased renal vascular resistance. The polyuria seems to be due to the impaired reabsorption rate in the distal nephron segments.
Original language | English |
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Journal | International Journal of Andrology |
Volume | 10 |
Issue number | 1 |
Pages (from-to) | 347-51 |
Number of pages | 4 |
ISSN | 0105-6263 |
Publication status | Published - 1987 |
Bibliographical note
Keywords: Animals; Cisplatin; Dogs; Erythrocyte Count; Glomerular Filtration Rate; Hematocrit; Hemoglobins; Kidney Tubules; Regional Blood Flow; Renal Circulation
ID: 8440337