Early electrocortical changes consistent with ischemic preconditioning in rat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Early electrocortical changes consistent with ischemic preconditioning in rat. / Zagrean, L.; Moldovan, M.; Munteanu, Ana-Maria; Spulber, St.; Voiculescu, B.A.; Popescu, B.O.

In: Journal of Cellular and Molecular Medicine, Vol. 4, No. 3, 2002, p. 215-223.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zagrean, L, Moldovan, M, Munteanu, A-M, Spulber, S, Voiculescu, BA & Popescu, BO 2002, 'Early electrocortical changes consistent with ischemic preconditioning in rat', Journal of Cellular and Molecular Medicine, vol. 4, no. 3, pp. 215-223.

APA

Zagrean, L., Moldovan, M., Munteanu, A-M., Spulber, S., Voiculescu, B. A., & Popescu, B. O. (2002). Early electrocortical changes consistent with ischemic preconditioning in rat. Journal of Cellular and Molecular Medicine, 4(3), 215-223.

Vancouver

Zagrean L, Moldovan M, Munteanu A-M, Spulber S, Voiculescu BA, Popescu BO. Early electrocortical changes consistent with ischemic preconditioning in rat. Journal of Cellular and Molecular Medicine. 2002;4(3):215-223.

Author

Zagrean, L. ; Moldovan, M. ; Munteanu, Ana-Maria ; Spulber, St. ; Voiculescu, B.A. ; Popescu, B.O. / Early electrocortical changes consistent with ischemic preconditioning in rat. In: Journal of Cellular and Molecular Medicine. 2002 ; Vol. 4, No. 3. pp. 215-223.

Bibtex

@article{68646760b45311df825b000ea68e967b,
title = "Early electrocortical changes consistent with ischemic preconditioning in rat",
abstract = "Ischemic preconditioning (IPC) of the brain describes the neuroprotection induced by a short, conditioning ischemic episode (CIE) to a subsequent severe (test) ischemic episode (TIE). Most of the supporting evidence for IPC is based on histological assessment, several days after TIE. The aim of this study is to investigate if changes induced by IPC can be detected within 30 min of reperfusion following the ischemic episode. A rat model of {"}four-vessel occlusion{"} transient global cerebral ischemia and parametric analysis of electrocorticogram were used. A control group was subjected directly to a 10 min TIE, and in a preconditioned group TIE was induced 48 h after a 3 min CIE. Quantitative histology was performed 48 h after TIE. Our key finding is that, 30 min after reperfusion, there is a significant increase in the electrocortical slow activity in the control group but not in the preconditioned group. Moreover the increase inversely correlates with the degree of electrocortical suppression during seconds 10 to 15 after the onset of the ischemic episode.",
author = "L. Zagrean and M. Moldovan and Ana-Maria Munteanu and St. Spulber and B.A. Voiculescu and B.O. Popescu",
year = "2002",
language = "English",
volume = "4",
pages = "215--223",
journal = "Journal of Cellular and Molecular Medicine",
issn = "1582-1838",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Early electrocortical changes consistent with ischemic preconditioning in rat

AU - Zagrean, L.

AU - Moldovan, M.

AU - Munteanu, Ana-Maria

AU - Spulber, St.

AU - Voiculescu, B.A.

AU - Popescu, B.O.

PY - 2002

Y1 - 2002

N2 - Ischemic preconditioning (IPC) of the brain describes the neuroprotection induced by a short, conditioning ischemic episode (CIE) to a subsequent severe (test) ischemic episode (TIE). Most of the supporting evidence for IPC is based on histological assessment, several days after TIE. The aim of this study is to investigate if changes induced by IPC can be detected within 30 min of reperfusion following the ischemic episode. A rat model of "four-vessel occlusion" transient global cerebral ischemia and parametric analysis of electrocorticogram were used. A control group was subjected directly to a 10 min TIE, and in a preconditioned group TIE was induced 48 h after a 3 min CIE. Quantitative histology was performed 48 h after TIE. Our key finding is that, 30 min after reperfusion, there is a significant increase in the electrocortical slow activity in the control group but not in the preconditioned group. Moreover the increase inversely correlates with the degree of electrocortical suppression during seconds 10 to 15 after the onset of the ischemic episode.

AB - Ischemic preconditioning (IPC) of the brain describes the neuroprotection induced by a short, conditioning ischemic episode (CIE) to a subsequent severe (test) ischemic episode (TIE). Most of the supporting evidence for IPC is based on histological assessment, several days after TIE. The aim of this study is to investigate if changes induced by IPC can be detected within 30 min of reperfusion following the ischemic episode. A rat model of "four-vessel occlusion" transient global cerebral ischemia and parametric analysis of electrocorticogram were used. A control group was subjected directly to a 10 min TIE, and in a preconditioned group TIE was induced 48 h after a 3 min CIE. Quantitative histology was performed 48 h after TIE. Our key finding is that, 30 min after reperfusion, there is a significant increase in the electrocortical slow activity in the control group but not in the preconditioned group. Moreover the increase inversely correlates with the degree of electrocortical suppression during seconds 10 to 15 after the onset of the ischemic episode.

M3 - Journal article

C2 - 12167290

VL - 4

SP - 215

EP - 223

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

SN - 1582-1838

IS - 3

ER -

ID: 21669005