Does liver-intestine significantly degrade circulating endogenous substance P in man?
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Does liver-intestine significantly degrade circulating endogenous substance P in man? / Henriksen, Jens Henrik Sahl; Schaffalitzky de Muckadell, O B; Bülow, J B.
In: Scandinavian Journal of Gastroenterology, Vol. 21, No. 3, 1986, p. 300-4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Does liver-intestine significantly degrade circulating endogenous substance P in man?
AU - Henriksen, Jens Henrik Sahl
AU - Schaffalitzky de Muckadell, O B
AU - Bülow, J B
N1 - Keywords: Adult; Aged; Female; Humans; Intestines; Liver; Male; Middle Aged; Substance P; Veins
PY - 1986
Y1 - 1986
N2 - Elevated concentrations of circulating substance P in patients with liver insufficiency have been ascribed to decreased hepatic degradation. To establish a possible biodegradation of the peptide in liver-intestine and kidneys, the concentration of endogenous immunoreactive substance P was determined in various vascular beds during a right-sided catheterization in 13 subjects without liver insufficiency. All subjects had normal values of circulating substance P, and no significant difference was found between systemic plasma and hepatic venous or renal venous concentrations of substance P. The results indicate that degradation of circulating endogenous substance P in man is not confined to liver-intestine or kidney but may take place in many tissues.
AB - Elevated concentrations of circulating substance P in patients with liver insufficiency have been ascribed to decreased hepatic degradation. To establish a possible biodegradation of the peptide in liver-intestine and kidneys, the concentration of endogenous immunoreactive substance P was determined in various vascular beds during a right-sided catheterization in 13 subjects without liver insufficiency. All subjects had normal values of circulating substance P, and no significant difference was found between systemic plasma and hepatic venous or renal venous concentrations of substance P. The results indicate that degradation of circulating endogenous substance P in man is not confined to liver-intestine or kidney but may take place in many tissues.
M3 - Journal article
C2 - 2424079
VL - 21
SP - 300
EP - 304
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 3
ER -
ID: 18838254