Cortical spreading depression in migraine
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Cortical spreading depression in migraine. / Lauritzen, M.
In: Cephalalgia, Vol. 21, No. 7, 01.12.2001, p. 757-760.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Cortical spreading depression in migraine
AU - Lauritzen, M.
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Cortical spreading depression (CSD) is associated with a dramatic failure of brain ion homeostasis as well as efflux of excitatory amino acids from nerve cells and increased energy metabolism. There is strong clinical and experimental evidence to suggest that CSD is involved in the mechanism of migraine. This paper will, based on the experience related to the detection of CSD in humans, discuss pitfalls and possible strategies for detection of CSD in man. Development of reliable methods for detection of CSD in humans will determine the extent to which the large body of experimental findings from animal studies of CSD can be applied to the investigation and treatment of human brain disease. The paper is based on the experience that has been gained from two decades of studies of CSD in relation to clinical neurological diseases.
AB - Cortical spreading depression (CSD) is associated with a dramatic failure of brain ion homeostasis as well as efflux of excitatory amino acids from nerve cells and increased energy metabolism. There is strong clinical and experimental evidence to suggest that CSD is involved in the mechanism of migraine. This paper will, based on the experience related to the detection of CSD in humans, discuss pitfalls and possible strategies for detection of CSD in man. Development of reliable methods for detection of CSD in humans will determine the extent to which the large body of experimental findings from animal studies of CSD can be applied to the investigation and treatment of human brain disease. The paper is based on the experience that has been gained from two decades of studies of CSD in relation to clinical neurological diseases.
KW - Cerebral blood flow
KW - Cortical spreading
KW - Depression
UR - http://www.scopus.com/inward/record.url?scp=0035741150&partnerID=8YFLogxK
U2 - 10.1046/j.1468-2982.2001.00244.x
DO - 10.1046/j.1468-2982.2001.00244.x
M3 - Review
C2 - 11595007
AN - SCOPUS:0035741150
VL - 21
SP - 757
EP - 760
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 7
ER -
ID: 200874638