Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

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Documents

  • Helena Bergsten
  • Martin Bruun Madsen
  • Francois Bergey
  • Hyldegaard, Ole
  • Steinar Skrede
  • Per Arnell
  • Oddvar Oppegaard
  • Andreas Itzek
  • Perner, Anders
  • Mattias Svensson
  • Anna Norrby-Teglund
  • INFECT Study Group

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume71
Issue number7
Pages (from-to)1772-1775
Number of pages4
ISSN1058-4838
DOIs
Publication statusPublished - 2020

    Research areas

  • Streptococcus pyogenes, intravenous immunoglobulin G, necrotizing fasciitis, necrotizing soft tissue infections, superantigens

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